摘要
目的探讨坤宝丸联合度洛西汀治疗女性围绝经期情绪障碍的效果。方法选取2023年3月至2024年3月赣州市第三人民医院收治的80例围绝经期情绪障碍患者作为研究对象,按照红蓝球法分为对照组(40例)与观察组(40例)。对照组采用口服度洛西汀肠溶胶囊方法,观察组采用口服度洛西汀结合坤宝丸的方法。比较两组的症状改善情况、治疗效果及不良反应。结果观察组治疗第4、8周抑郁、焦虑、围绝经期评分低于对照组,差异有统计学意义(P<0.05);观察组中、西医治疗评定总有效率均高于对照组,差异有统计学意义(P<0.05);两组患者的不良反应总发生率比较,差异无统计学意义(P>0.05)。结论对于围绝经期情绪障碍患者,通过采取坤宝丸、度洛西汀联合治疗具有一定优势,有助于改善患者的临床症状,且安全性较高,可进行临床推广。
Objective To explore the effect of Kunbao Pill combined with Duloxetine on perimenopausal mood disorders in women.Methods A total of 80 patients with perimenopausal mood disorders admitted to Ganzhou Third People's Hospital from March 2023 to March 2024 were selected as the study objects,and the patients were divided into control group(40 cases)observation group(40 cases)by red ball basketball classification.The control group took oral Duloxetine enteric capsules,and the observation group was used in combination with Kunbao Pills.Symptom improvement,therapeutic effect and adverse reactions were compared between the two groups.Results The depression,anxiety and Greene peri-menopause scales in the 4th and 8th week of the treatment in the observation group were lower than those of the control group,and the differences were statistically significant(P<0.05).The total response rate of traditional Chinese and Western medicine treatment evaluation in the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).There was no significant difference(P>0.05)in the total incidence of bad events of the two groups.Conclusion For patients with perimenopausal mood disorders,the combination treatment of Kunbao Pill and Duloxetine has certain advantages,which is helpful to improve the clinical symptoms of patients,and has high safety,or further clinical promotion of forestry.
作者
蔡文婷
姜彬贵
赖忠红
张萍萍
何述亮
CAI Wenting;JIANG Bingui;LAI Zhonghong;ZHANG Pingping;HE Shuliang(Department of Psychiatry,Ganzhou Third People's Hospital,Jiangxi Province,Ganzhou341000,China)
出处
《中国当代医药》
CAS
2024年第33期46-49,共4页
China Modern Medicine
基金
江西省中医药管理局科技计划项目(2023B0369)。
关键词
围绝经期情绪障碍
坤宝丸
度洛西汀
症状改善
治疗效果
不良反应
Perimenopausal mood disorder
Kunbao Pill
Duloxetine
Symptom improvement
Treatment effect
Adverse reaction
