摘要
目的分析激素治疗(MHT)干预对围绝经期女性乳腺病变的影响,为围绝经期女性改善MHT干预效果提供依据。方法 选取杭州市妇产科医院就诊的40~60岁围绝经期综合征患者为研究对象,接受MHT干预的患者纳入干预组,并根据MHT干预方案分为雌孕激素周期治疗组(A组)、雌孕激素连续联合治疗组(B组)和单雌激素治疗组(C组);未干预患者为对照组。所有患者定期接受乳腺钼靶检查,采用广义估计方程分析干预组与对照组乳腺病变情况。结果干预组80例,其中A组49例、B组26例、C组5例;对照组80例。经过2年随访,干预组与对照组的乳腺密度、乳腺纤维组织容积、乳房容积干预前后差异、组间差异及组间与时间交互作用均无统计学意义(P>0.05);干预组与对照组的乳房钙化检出率和乳房肿块检出率干预前后差异有统计学意义(P<0.05),组间差异及组间与时间交互作用均无统计学意义(P>0.05)。结论 未发现围绝经期女性的乳腺病变风险与MHT干预有关。
Objective To explore the correlation between menopausal hormone therapy(MHT)and breast lesions in perimenopausal women,and to provide evidence for safe use of MHT.Methods The 40-60 year-old women who visited Hangzhou Women's Hospital and met the diagnostic criteria for perimenopausal syndrome were recruited.The intervention group received MHT and was divided into three subgroups according to the MHT regimen:estrogen-progesterone cycle therapy(A),estrogen-progesterone continuous therapy(B),estrogen therapy(C).The control group did not receive MHT.All the patients received regular mammography to quantify and evaluate breast lesions.The generalized estimating equation was used to analyze the changes of breast lesions between different groups.Results There were 80 cases in the intervention group,with 49 in group A,26 in group B,5 in group C,and 80 cases in the control group.After two years of follow-up,there was no statistically significant differences of time,group and interaction in breast density,volume of breast fibrous tissue and the volume of breast between three intervention groups and the control group(P>0.05);there was no statistically significant differences of group and interaction in positive rate of calcification and breast mass between the intervention group and the control group(P>0.05).Conclusion Receiving MHT intervention for two years did not increase the risk of breast lesions.
作者
马林
黄坚
陈临节
楼向明
周健
夏建余
陆晨蕾
吴红艳
张治芬
A Lin;HUANG Jian;CHEN Lin-jie;LOU Xiang-ming;ZHOU Jian;XIA Jian-yu;LU Chen-lei;WU Hong-yan;ZHANG Zhi-fen(Department of Gynecology,Hangzhou Women's Hospital,Hangzhou,Zhejiang 310008,China)
出处
《预防医学》
2019年第9期882-885,共4页
CHINA PREVENTIVE MEDICINE JOURNAL
基金
浙江省科技计划项目(2017C33203)
杭州市科技发展计划项目(20140733Q16)
关键词
围绝经期
绝经激素治疗
乳腺密度
乳房钙化
乳腺纤维组织容积
Peri-menopause
Menopausal hormone therapy
Breast density
Breast calcification
Breast fibrous tissue volume
