摘要
胃癌前病变(gastric precancerous lesions,GPL)是胃黏膜慢性炎症病理逐步癌变转化的过程,而机体免疫状态及表型转换是胃癌前病变的核心调控机制。本文系统性总结不同免疫细胞在胃癌前病变过程中成熟、分化、炎症浸润及活化的关键分子事件,深入分析病灶免疫微环境中不同免疫细胞、免疫细胞与非免疫细胞相互间对话机制;并基于“扶正祛邪”探讨中医药靶向免疫细胞干预胃癌前病变的特色优势与前景应用,将为胃癌前病变的免疫干预及药物研发提供了新的思路和方法。
Gastric precancerous lesions(GPL)represent the gradual transformation of chronic gastric mucosal inflammation into cancerous state,with the host’s immune status and phenotypic shifts serving as pivotal regulatory mechanisms.This review systematically summarized the critical molecular events associated with the maturation,differentiation,inflammatory infiltration,and activation of various immune cells throughout the progression of gastric precancerous lesions.It further delved into the intercellular dialogue mechanisms within the immune microenvironment at the lesion site,encompassing interactions between diverse immune cells and between immune and non-immune cells.Drawing upon the traditional Chinese medical principle of“reinforcing the healthy qi to eliminate pathogenic factors”,the paper explored the distinctive advantages and potential applications of traditional Chinese medicine in targeting immune cells for the intervention of gastric precancerous lesions.This approach offered novel perspectives and methods for immune intervention and pharmaceutical development in gastric precancerous lesions.
作者
刘雪雯
刘乃华
潘华峰
LIU Xuewen;LIU Naihua;PAN Huafeng(Science and Technology Innovation Center,Guangzhou University of Chinese Medicine,Guangzhou 510405 Guangdong,China)
出处
《中医肿瘤学杂志》
2024年第6期113-122,共10页
Journal of Oncology in Chinese Medicine
基金
国家自然科学基金资助项目(编号:82174319,82305169)
广东省重大专项(编号:2020B1111100011)
国家中医药传承创新团队资助项目(编号:ZYYCXTD-C-202208)
广东省自然科学基金项目(编号:2023A1515010751)
中国博士后科学基金面上资助(编号:2023M730811)。
关键词
胃癌前病变
炎症损伤
免疫细胞
细胞对话
免疫干预
gastric precancerous lesions
inflammatory injury
immune cells
intercellular communication
immune intervention
