摘要
目的 探究急性脑梗死溶栓治疗后血清长链非编码RNA CAI2 (LncRNA CAI2)、尿酸(UA)、同型半胱氨酸(Hcy)和脑血流灌注、神经功能的变化。方法 选取2020年8月至2023年3月于阜阳市肿瘤医院神经内科进行治疗的85例急性脑梗死患者为研究对象,根据患者的治疗方案进行分组,将40例行常规治疗患者纳入对照组,45例于溶栓治疗基础上行常规治疗患者纳入溶栓组。比较2组患者临床疗效、血清LncRNA CAI2、UA、Hcy水平和脑血流灌注指标、神经功能的恢复情况、脑血流参数以及溶栓后不良反应的发生情况。结果 溶栓组临床总有效率为97.78%(44/45),高于对照组的82.50%(33/40)(P <0.05);治疗后24 h,2组LncRNACAI2和Hcy水平均下降,UA水平均上升,且溶栓组变化更显著(P <0.05);治疗后,2组患者局部脑血容量(rCBV)和局部脑血流量(rCBF)均升高,对比剂平均通过时间(MTT)均下降,且溶栓组变化更显著(P <0.05);治疗后,2组美国国立卫生研究院卒中量表(NIHSS)评分均下降,简易精神状态检查量表(MMSE)评分均升高,且溶栓组变化更显著(P <0.05);治疗后,2组阻力指数(RI)和搏动指数(PI)均下降,平均血流速度(Vm)均升高,且溶栓组变化更显著(P <0.05);2组转氨酶升高、皮疹、呕吐、恶心、肾功能损伤等不良反应发生情况比较差异无统计学意义(P> 0.05)。结论 溶栓治疗能有效提高急性脑梗死患者的治疗效果,改善血清LncRNA CAI2、UA、Hcy水平和脑血供情况,促进患者神经功能恢复,且不增加不良反应。
Objective To explore the changes in serum long non-coding RNA CAI2(LncRNA CAI2),uric acid(UA),homocysteine(Hcy)levels,cerebral blood flow perfusion,and neurological function following thrombolytic therapy for acute cerebral infarction.Methods 85 patients with acute cerebral infarction who underwent treatment at Fuyang Cancer Hospital from August 2020 to March 2023 were selected as the study subjects.According to the treatment plan,the patients were divided into two groups,and 40 patients receiving conventional treatment were included in the control group.The clinical efficacy,serum LncRNA CAI2,UA,Hcy levels,cerebral blood flow perfusion indicators,neurological function recovery,cerebral blood flow parameters,and the incidence of postoperative adverse reactions were compared between the two groups.Results The total effective rate of clinical treatment in the thrombolysis group was 97.78%(44/45),which was higher than 82.50%(33/40)in the control group(P<0.05).After treatment,the levels of LncRNA CAI2 and Hcy decreased in both groups,while the levels of UA increased.The changes in the thrombolysis group were more significant(P<0.05).After treatment,both groups showed an increase in rCBV and rCBF,a decrease in MTT,and more significant changes in the thrombolysis group(P<0.05).After treatment,both groups showed a decrease in NIHSS scores and an increase in MMSE scores,with more significant changes observed in the thrombolysis group(P<0.05).After treatment,both RI and PI decreased,while Vm increased in both groups,and the changes in the thrombolysis group were more significant(P<0.05).There was no statistical difference in the incidence of adverse reactions such as elevated transaminases,rash,vomiting,nausea,and renal function damage between the two groups(P>0.05).Conclusion Intraveno us thrombolysis can effectively improve the treatment effectiveness of patients with acute cerebral infarction,optimize serum levels of LncRNA CAI2,UA,and Hcy,and improve cerebral blood supply. In addition, the recovery of neurological fun
作者
周丽
夏元亮
杜威
王亚军
张学东
ZHOU Li;XIA Yuanliang;DU Wei;WANG Yajun;ZHANG Xuedong(Department of Neurology,Fuyang Cancer Hospital,Fuyang,Anhui 236000,China)
出处
《转化医学杂志》
2024年第3期334-339,共6页
Translational Medicine Journal
基金
安徽省自然科学基金项目(2308085QH374)。
关键词
脑梗死
静脉溶栓
脑血流灌注
神经功能
血清长链非编码RNA
CAI2
同型半胱氨酸
尿酸
Acute cerebral infarction
Intravenous thrombolysis
Cerebral blood flow perfusion
Neurological function
Long-chain non-coding RNA CAI2
Homocysteine
Uric acid
