摘要
目的探讨血尿酸(UA)、N末端B型利钠肽原(NT-proBNP)、血小板与淋巴细胞比值(PLR)在急性脑梗死(AIS)静脉溶栓中动态变化及意义。方法选取沧州市人民医院105例AIS患者,均行静脉溶栓治疗,根据发病90 d改良Rankin量表评分(mRS)分为预后不良组(n=26)、良好组(n=79),比较两组溶栓前、溶栓后24 h、溶栓后7 d UA、NT-proBNP、PLR水平及发病90 d mRS评分,分析预后的相关影响因素,并分析溶栓后24 h、溶栓后7 d UA、NT-proBNP、PLR水平与发病90 d mRS评分关系及预测预后不良的价值。结果不良组溶栓后24 h、溶栓后7 d UA、NT-proBNP、PLR水平均高于良好组,差异有统计学意义(P<0.05);不良组发病后90 d mRS评分高于良好组,差异有统计学意义(P<0.05);溶栓后24 h、溶栓后7 d UA、NT-proBNP、PLR水平与发病后90 d mRS评分间存在正相关关系(P<0.05),与AIS患者预后显著相关(P<0.05);溶栓后24 h、溶栓后7 d UA、NT-proBNP、PLR预测AIS患者预后不良的曲线下面积(AUC)均>0.7,溶栓后7 d各指标联合预测的AUC最大,为0.953。结论UA、NT-proBNP、PLR水平在脑梗死静脉溶栓中随着病情改善逐渐降低,与患者预后显著相关,可辅助临床预测患者预后转归方向。
Objective To investigate the dynamic changes and significance of blood uric acid(UA),N-terminal pro-B-type natriuretic peptide(NT-proBNP),platelet to lymphocyte ratio(PLR)in acute cerebral infarction(AIS)intravenous thrombolysis.Methods A total of 105 AIS patients from the People.s Hospital of Cangzhou City were selected for intravenous thrombolysis.According to the modified Rankin scale score(mRS)at 90 days after the onset,they were divided into a poor prognosis group(n=26)and a good group(n=79).Before thrombolysis,24 h after thrombolysis,7 d after thrombolysis,UA,NT-proBNP,PLR levels and 90 d mRS score after thrombolysis,analysis of prognostic related factors,and analysis of 24 h after thrombolysis,7 days after thrombolysis d The relationship between UA,NT-proBNP,PLR levels and mRS score at 90 days after the onset of onset,and the value of predicting poor prognosis.Results 24 hours afterthrombolysis and 7 days after thrombolysis in the poor group,the levels of UA,NT-proBNP,and PLR were higher than those in the good group(P<0.05);the m RS score of the bad prognosis group was higher than that in the good prognosis group at 90 days after the onset of thrombolysis(P<0.05);24 hours after thrombolysis,7 days after thrombolysis,UA,NT-proBNP,PLR levels and 90 days after the onset of m RS scores were positively correlated(P<0.05);24 hours after thrombolysis,7 days after thrombolysis UA,NT-proBNP and PLR are all significantly correlated with the prognosis of AIS patients(P<0.05);24 h after thrombolysis and 7 days after thrombolysis UA,NT-proBNP,PLR predict the poor prognosis area under the curve(AUC)of AIS patients Both were>0.7.The combined prediction of AUC of each index was the largest at 7 days after thrombolysis,which was 0.953.Conclusion The levels of UA,NT-proBNP,and PLR in intravenous thrombolysis of cerebral infarction gradually decrease with the improvement of the disease,and are significantly related to the patient.s prognosis,which can help clinically predict the direction of the patient.s prognosis.
作者
孙维明
王桂华
张颖
齐霄茹
冯晨芳
SUN Weiming;WANG Guihua;ZHANG Ying;QI Xiaoru;FENG Chengfang(Division 1,Department of cerebrovascular disease(intervention),Cangzhou people's Hospital,Cangzhou,Hebei,China,061000;Department of gastrointestinal surgery,Cangzhou people's Hospital,Cangzhou,Hebei,China,061000;Department of Neurology,Cangzhou people's Hospital,Cangzhou,Hebei,China,061000;Second District,Department of cerebrovascular disease(intervention),Cangzhou people’s Hospital,Cangzhou,Hebei,China,061000)
出处
《分子诊断与治疗杂志》
2021年第10期1639-1643,共5页
Journal of Molecular Diagnostics and Therapy
基金
沧州市科学计划自筹经费项目(183302070)。
关键词
急性脑梗死
血尿酸
N末端B型利钠肽原
血小板与淋巴细胞比值
静脉溶栓
Acute cerebral infarction
Blood uric acid
N-terminal pro-B-type natriuretic peptide
Platelet to lymphocyte ratio
Intravenous thrombolysis
