摘要
目的观察消渴丸联合二甲双胍及胰岛素治疗2型糖尿病(T2DM)的效果及对患者血糖、血脂、氧化应激的影响。方法前瞻性选取60例T2DM患者,根据随机数字表法将其分为观察组(采用消渴丸+胰岛素+二甲双胍治疗)和对照组(采用二甲双胍+胰岛素治疗),各30例,均治疗12周。比较两组患者治疗前后的中医证候积分、血糖指标[空腹血糖(FBG)、餐后2 h血糖(2 h PG)、糖化血红蛋白(HbA1c)]、血脂指标[总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)]以及氧化应激指标[超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)、丙二醛(MDA)]水平,治疗效果,不良反应发生情况。结果治疗后,两组患者口干多饮、多食易饥、小便频数、乏力倦怠、认知受损积分均显著低于治疗前,且观察组患者口干多饮、多食易饥、小便频数、乏力倦怠、认知受损积分分别为(0.61±0.17)、(0.54±0.18)、(0.40±0.28)、(0.59±0.14)、(0.54±0.12)分,低于对照组的(1.13±0.26)、(1.05±0.37)、(1.06±0.36)、(1.04±0.12)、(1.02±0.15)分(P<0.05)。治疗后,两组患者FBG、2 h PG、HbA1c均低于治疗前,且观察组患者FBG、2 h PG、HbA1c分别为(7.33±1.04)mmol/L、(9.15±1.56)mmol/L、(6.42±1.14)%,低于对照组的(8.26±1.02)mmol/L、(10.17±1.38)mmol/L、(7.26±1.09)%(P<0.05)。治疗后,两组患者TC、TG、LDL-C均低于治疗前,且观察组患者TC(3.66±1.03)mmol/L、TG(1.46±0.53)mmol/L、LDL-C(2.48±0.63)mmol/L低于对照组的(4.27±1.25)、(1.78±0.67)、(3.06±0.87)mmol/L;HDL-C高于治疗前,且观察组HDL-C(1.42±0.12)mmol/L高于对照组的(1.36±0.04)mmol/L(P<0.05)。治疗后,两组患者SOD与GSH-Px高于治疗前,且观察组SOD(88.43±16.84)U/ml、GSH-Px(31.01±4.03)U/ml明显高于对照组的(78.48±16.37)、(28.06±3.18)U/ml;MDA低于治疗前,且观察组MDA(7.17±2.16)μmol/L低于对照组的(8.42±2.64)μmol/L(P<0.05)。观察组总有效率为90.00%(27/30),�
Objective To observe the effect of Xiaoke Pill combined with metformin and insulin in the treatment of type 2 diabetes mellitus(T2DM)and its impact on blood glucose,blood lipids and oxidative stress.Methods A prospective study was conducted on 60 patients with T2DM were included in the study.They were divided into an observation group(treated with Xiaoke Pill combined with insulin and metformin)and a control group(treated with metformin and insulin)by random number table method,each consisting of 30 cases.All patients were given 12 weeks of treatment.Patients in both groups were compared in terms of traditional Chinese medicine syndrome score,blood glucose indicators[fasting blood glucose(FBG),2-h postprandial glucose(2 h PG)and glycated hemoglobin(HbA1c)],blood lipid indicators[total cholesterol(TC),triacylglycerol(TG),low-density lipoprotein cholesterol(LDL-C)and high-density lipoprotein cholesterol(HDL-C)]and oxidative stress indicators[superoxide dismutase(SOD),glutathione peroxidase(GSH-Px)and malondialdehyde(MDA)],therapeutic effect,and occurrence of adverse reactions.Results After treatment,the scores of dry mouth and polydipsia,hyperphagia and swift hungering,frequent urination,fatigue and cognitive impairment in both groups were significantly lower than those before treatment;in the observation group,the scores of dry mouth and polydipsia,hyperphagia and swift hungering,frequent urination,fatigue and cognitive impairment were(0.61±0.17),(0.54±0.18),(0.40±0.28),(0.59±0.14)and(0.54±0.12)points,which were lower than(1.13±0.26),(1.05±0.37),(1.06±0.36),(1.04±0.12)and(1.02±0.15)points in the control group(P<0.05).After treatment,FBG,2 h PG and HbA1c in both groups were lower than those before treatment;FBG,2 h PG and HbA1c were(7.33±1.04)mmol/L,(9.15±1.56)mmol/L and(6.42±1.14)%in the observation group,which were lower than(8.26±1.02)mmol/L,(10.17±1.38)mmol/L and(7.26±1.09)%in the control group(P<0.05).After treatment,TC,TG and LDL-C in both groups were lower than those before treatment,while HD
作者
刘家焕
管花
徐恭妹
LIU Jia-huan;GUAN Hua;XU Gong-mei(Shangping Health Center,Yong'an 366000,China)
出处
《中国现代药物应用》
2024年第21期25-29,共5页
Chinese Journal of Modern Drug Application
关键词
消渴丸
二甲双胍
胰岛素
2型糖尿病
血糖调节
血脂指标
氧化应激
疗效
Xiaoke Pill
Metformin
Insulin
Type 2 diabetes mellitus
Blood glucose regulation
Blood lipid indicators
Oxidative stress
Curative effect
