摘要
目的:探究益肾活络汤联合二甲双胍对老年2型糖尿病(T2DM)患者血糖、胰岛素抵抗的影响。方法:选取104例老年T2DM患者,按照随机数字表法分为西药组(n=52)和联合组(n=52),所有患者均给予常规治疗,西药组给予二甲双胍治疗,联合组在西药组基础上予以益肾活络汤治疗。比较两组患者临床疗效、中医症状积分,治疗前后糖代谢、胰岛素抵抗指数(IR)、体重指数(BMI)、血清视黄醇结合蛋白-4(RBP-4)、血清胱抑素C(CYS-C)、同型半胱氨酸(HCY)及不良反应。结果:联合组治疗总有效率90.38%高于西药组的76.92%,差异有统计学意义(P<0.05)。治疗后两组患者咽干舌燥、倦怠无力、多饮、多食、气短、五心烦热评分均下降,且治疗后联合组症状评分低于西药组,差异有统计学意义(均P<0.05)。治疗后,两组患者糖代谢相关指标、HOMA-IR、BMI、RBP-4、CYS-C、HCY下降,且联合组低于西药组,差异有统计学意义(均P<0.05)。西药组中1例轻度低血糖、1例消化不良,联合组1例轻度低血糖、2例胃肠道不适,两组不良反应发生率比较,差异无统计学意义(χ^(2)=0.210,P=0.647)。结论:益肾活络汤联合二甲双胍可改善老年T2DM患者临床症状,稳定其糖代谢,延缓T2DM及其并发症进展。
Objective:To investigate influence of Yishen Huoluo decoction combined with metformin on blood glucose and insulin resistance in elderly patients with type 2 diabetes mellitus(T2DM).Methods:104 elderly patients with T2DM were selected.According to the random number table method,they were divided into western medication group(n=52)and combination group(n=52).All patients were given conventional treatment,the western medication group were treated with metformin,and the combination group treated with Yishen Huoluo decoction on the basis of the western medication group.Clinical efficacy,TCM symptoms scores,glucose metabolism,insulin resistance index(IR),body mass index(BMI),serum RBP-4,CYS-C and HCY before and after treatment and adverse reactions were compared.Results:The total effective rate of treatment in the combined group 90.38%was higher than that in the western medication group 76.92%,difference statistically significant(P<0.05).After treatment,the scores of dry mouth,fatigue,dry mouth and polydipsia,hunger,shortness of breath and lazy speech,five irritable heat in the two groups were decreased,and the symptoms scores were lower in the combined group,difference statistically significant(all P<0.05).The glucose metabolism,HOMA-IR,BMI,RBP-4,CYS-C and HCY were reduced in both groups after treatment,and the above indicators in the combined group after treatment were lower than those in the western medication group,difference statistically significant(all P<0.05).There were one case of mild hypoglycemia,one case of dyspepsia in the western medication group,and one case of mild hypoglycemia,two cases of gastrointestinal discomfort in the combination group,difference not statistically significant(χ^(2)=0.210,P=0.647).Conclusion:Combination of Yishen Huoluo decoction and metformin can improve clinical symptoms,stabilize glucose metabolism,and delay the progression of T2DM and its complications in elderly patients with T2DM.
作者
杨丰贤
张静
陈风彩
YANG Fengxian;ZHANG Jing;CHEN Fengcai(Qingdao Hiser Hospital Affiliated of Qingdao University,Qingdao Traditional Chinese Medicine Hospital,Qingdao 266033,China)
出处
《陕西中医》
CAS
2024年第11期1504-1507,共4页
Shaanxi Journal of Traditional Chinese Medicine
基金
山东省中医药科技项目(2020Q115)。
关键词
2型糖尿病
益肾活络汤
二甲双胍
胰岛素抵抗
糖代谢
血清视黄醇结合蛋白-4
Type 2 diabetes mellitus
Yishen Huoluo decoction
Metformin
Insulin resistance
Glucose metabolism
Serum retinol-binding protein-4