摘要
目的探究马来酸依那普利叶酸辅助苯磺酸氨氯地平对老年H型高血压患者血压变异性、血清同型半胱氨酸(Hcy)水平及动脉硬化的影响。方法选取聊城市茌平区第二人民医院2020年4月—2023年4月收治的90例老年H型高血压患者为研究对象,按随机数字表法将其分为对照组与观察组,各45例。对照组采用苯磺酸氨氯地平治疗,观察组在对照组的基础上加用马来酸依那普利叶酸治疗。比较两组血压变异性、血清学指标、动脉硬化状况及不良反应发生情况。结果治疗后,观察组的24 h平均收缩压、24 h平均舒张压、24 h收缩压变异性平均值及24 h舒张压变异性平均值水平均低于对照组,组间差异有统计学意义(P<0.05);观察组血清Hcy、尿酸(UA)及血流阻力指数水平均低于对照组,颈总动脉内中膜厚度薄于对照组,组间差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论马来酸依那普利叶酸联合苯磺酸氨氯地平可改善老年H型高血压患者血压变异性,降低血清Hcy、UA水平,延缓动脉硬化,且用药安全性较好。
Objective To investigate the effects of enalapril maleate folic acid assisted amlodipine besylate on blood pressure variability,serum homocysteine(Hcy)levels and atherosclerosis in elderly patients with H-type hypertension.Methods A total of 90 elderly patients with H-type hypertension admitted in Chiping Distric Liaocheng City Second People's Hospital from April 2020 to April 2023 were selected as the research subjects.According to random number table method,they were divided into a control group and an observation group,with 45 cases in each group.The control group was treated withamlodipine besylate,and the observation group was treated with enalapril maleate folic acid on the basis of the control group.The blood pressure variability,serological indexes,arteriosclerosis status and the occurrence of adverse reactions were compared between the two groups.Results After treatment,24 h mean systolic blood pressure,24 h mean diastolic blood pressure,24 h mean systolic blood pressure variability and 24 h mean diastolic blood pressure variability in the observation group were lower than those in the control group,and the differences between groups were statistically significant(P<0.05);the levels of serum Hcy,uric acid(UA)and blood flow resistance index in the observation group were lower than those in the control group,and the intima-media thickness of the common carotid artery was thinner than that in the control group,and the differences between groups were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The combination of enalapril maleate folic acid with amlodipine besylate can improve blood pressure variability in elderly patients with H-type hypertension,reduce serum Hcy and UA levels,delay arteriosclerosis,and have good medication safety.
作者
张俊池
李金环
ZHANG Junchi;LI Jinhuan(Department of Internal Medicine,Chiping District Liaocheng City Second People's Hospital,Liaocheng 252000,China;Department of Gynecology,Chiping District Liaocheng City Second People's Hospital,Liaocheng 252000,China)
出处
《反射疗法与康复医学》
2024年第17期138-140,148,共4页
Reflexology And Rehabilitation Medicine
关键词
H型高血压
老年
马来酸依那普利叶酸
苯磺酸氨氯地平
H-type hypertension
Elderly
Enalapril Maleate Folic Acid
Amlodipine besylate
Blood pressure variability
