摘要
目的:比较苯磺酸氨氯地平叶酸片与马来酸依那普利叶酸片治疗H型高血压患者的有效性和安全性。方法:选取160例于2019年1月至2020年1月在广西医科大学附属武鸣医院就诊且首次诊断为H型高血压的广西壮族患者,通过随机数字表法分为观察组和对照组,每组80例。观察组患者采用苯磺酸氨氯地平叶酸片治疗,对照组患者采用马来酸依那普利叶酸片治疗,两组患者均治疗6个月。观察两组患者的临床疗效、治疗前后血压[收缩压(SBP)、舒张压(DBP)]、同型半胱氨酸(Hcy)水平、不良反应发生情况和心脑血管不良事件发生情况。结果:观察组和对照组患者的总有效率分别是88.75%(71/80)和83.75%(67/80),观察组患者的总有效率更高,但差异无统计学意义(P>0.05)。与治疗前相比,两组患者治疗后的SBP、DBP和Hcy水平明显降低,且观察组患者治疗后的SBP、DBP和Hcy水平降幅比对照组更大,差异均有统计学意义(P<0.05)。治疗6个月内,观察组患者的心脑血管不良事件发生率为3.75%(3/80),对照组患者为10.00%(8/80),两组的差异无统计学意义(P>0.05)。观察组患者的不良反应发生率为6.25%(5/80),明显低于对照组的16.25%(13/80),差异有统计学意义(P<0.05)。结论:苯磺酸氨氯地平叶酸片治疗H型高血压患者,降低血压和Hcy水平的效果更优,且不良反应发生率更低。
OBJECTIVE:To compare the efficacy and safety of Amlodipine besylate folic acid tablets and Enalapril maleate folic acid tablets in the treatment of H-type hypertension patients.METHODS:A total of 160 Guangxi Zhuang patients diagnosed with H-type hypertension for the first time in Wuming Hospital,Guangxi Medical University from Jan.2019 to Jan.2020 were extracted to be divided into the observation group and the control group via the random number table,with 80 cases in each group.The observation group was treated with Amlodipine besylate folic acid tablets,while the control group received Enalapril maleate folic acid tablets,both groups were treated for 6 months.Clinical efficacy,blood pressure[systolic pressure(SBP)and diastolic pressure(DBP)],homocysteine(Hcy)level,adverse drug reactions and cardiovascular and cerebrovascular adverse events before and after treatment in two groups were observed.RESULTS:The total effective rate of the observation group and the control group was respectively 88.75%(71/80)and 83.75%(67/80),the total effective rate of the observation group was higher than that in the control group,the difference was not statistically significant(P>0.05).Compared with before treatment,the levels of SBP,DBP and Hcy in two groups decreased significantly after treatment,and the decrease of SBP,DBP and Hcy in the observation group was greater than that in the control group,the differences were statistically significant(P<0.05).Within 6 months of treatment,the incidence of cardiovascular and cerebrovascular adverse events was 3.75%(3/80)in the observation group and 10.00%(8/80)in the control group,with no statistically significant difference(P>0.05).The incidence of adverse drug reactions was 6.25%(5/80)in the observation group,significantly lower than 16.25%(13/80)in the control group,the difference was statistically significant(P<0.05).CONCLUSIONS:Amlodipine benzoate folic acid tablets for H-type hypertension patients shows better results in lowering blood pressure and Hcy levels and lower incidence of
作者
李龙
黄静媛
吴锦斌
潘华生
宁奉星
黄流强
LI Long;HUANG Jingyuan;WU Jinbin;PAN Huasheng;NING Fengxing;HUANG Liuqiang(Dept.of Cardiovasology,Wuming Hospital,Guangxi Medical University,Guangxi Nanning 530199,China)
出处
《中国医院用药评价与分析》
2021年第9期1036-1038,1043,共4页
Evaluation and Analysis of Drug-use in Hospitals of China
基金
广西壮族自治区卫生和计划生育委员会自筹经费科研课题(No.Z20180236)。
关键词
H型高血压
苯磺酸氨氯地平叶酸片
马来酸依那普利叶酸片
壮族
H-type hypertension
Amlodipine besylate folic acid tablets
Enalapril maleate folic acid tablets
Zhuang nationality
