摘要
目的对阿克苏地区2018—2020年HIV-1抗体确证检测结果进行回顾性统计分析,为制定艾滋病防控策略提供科学依据。方法收集本地区2018—2020年下辖各实验室送检的HIV检测待确证样本,经剔重复核,利用蛋白质印迹(Western blot,WB)法进行确证,再用SPSS 22.0对该实验数据进行χ^(2)检验分析。结果在HIV-1抗体确证阳性的2109例样本中,男性1305例,男女性别比为1.34∶1,20~<40岁年龄组占92.1%,维吾尔族占92.6%,已婚者占89.7%,初中文化程度者占93.2%,农牧民占91.9%,样本来源于全民体检的占93.2%,感染途径为性传播的占93.1%。不同年份、民族、婚姻状况、样本来源、感染途径的样本,HIV抗体阳性率差异均有统计学意义(χ^(2)=11.212、13.575、37.331、231.733、25.514,均P<0.05)。在确证阳性的各种带型中,阳性率检出最高的基因组是env带,其中gp160占100.0%,pol带p66占99.9%,env带gp41的阳性检出率最低,占96.7%。结论阿克苏地区HIV-1抗体确证检测结果显示,不同年份、民族、婚姻状况、样本来源、感染途径的HIV/AIDS病例WB带型均存在差异。加强对本辖区内各实验室规范化管理与技术指导的力度,提高早发现早治疗的效率,为艾滋病防治提供科学依据。
Objective To conduct a retrospective statistical analysis of the results of HIV-1 antibody confirmatory testing in Aksu Region from 2018 to 2020,so as to provide a scientific basis for the development of AIDS prevention and control strategies.Methods Samples for HIV testing sent to various laboratories under the jurisdiction of the region from 2018 to 2020 were collected.After eliminating duplicates and rechecking,confirmation was conducted using the Western blot(WB)method,followed by analysis of the experimental data usingχ^(2)-test with SPSS 22.0.Results Among the 2109 samples with confirmed HIV-1 antibody positivity,1305 were males,with a male-to-female ratio of 1.34∶1.The age group of 20-<40 years accounted for 92.1%.Uyghur ethnicity comprised 92.6%of the cases,married individuals accounted for 89.7%,those with a junior high school education comprised 93.2%,farmers and herders constituted 91.9%,samples from universal medical checkups constituted 93.2%,and sexual transmission of infections accounted for 93.1%.Differences in HIV antibody positivity rates were statistically significant for samples of different years,ethnicities,marital statuses,sample sources,and routes of infection(χ^(2)=11.212,13.575,37.331,231.733,25.514,all P<0.05).Among various band types of confirmed positivity,the env band exhibited the highest positive detection rate,with gp160 accounting for 100.0%,the pol band p66 at 99.9%,while the lowest positive detection rate was observed in the env band gp41,at 96.7%.Conclusion The results of HIV-1 antibody confirmation testing in the Aksu Region all reveal differences in WB banding types among HIV/AIDS cases across different years,ethnic groups,marital statuses,sample sources,and routes of infection.Strengthening standardized management and technical guidance in various laboratories within this jurisdiction can enhance the efficiency of early detection and treatment,thereby providing a scientific basis for AIDS prevention and treatment.
作者
冯疆涛
孙路明
周煜凡
热衣汗古丽·卡地尔
杨越
许铭玉
董伟
李虎
戴浈浈
FENG Jiangtao;SUN Luming;ZHOU Yufan;Reyihanguli·Kadier;YANG Yue;XU Mingyu;DONG Wei;LI Hu;DAI Zhenzhen(Department of clinical Laboratory,Center for Disease Control and Prevention of Aksu Prefecture,Aksu,Xinjiang Uygur Autonomous Region 843000,China;不详)
出处
《医学动物防制》
2024年第10期1037-1040,F0003,共5页
Journal of Medical Pest Control
基金
新疆塔里木大学校长基金人才项目(TDZKSS202320)
2023年中央财政重大传染病防控项目[阿地财社(2023)21号]。
