摘要
目的目前中药发酵研究存在发酵机理不明确、工艺技术落后、质量评价标准不够系统化等问题,未能将中药发酵饮片的疗效发挥至佳,且难以达到工艺规范化、规格一致化、设备智能化。因此,需进一步对中药发酵饮片进行炮制方法的探索、炮制原理的验证及炮制工艺的现代化研究,为中药发酵技术的发展提供参考依据。方法通过文献分析及古籍查阅,对中药传统发酵方法进行考证与归纳,总结中药发酵的相关研究,从发酵菌种、发酵形式、发酵设备、工艺优化、发酵机理、化学成分变化及药理作用变化和应用研究等方面对中药发酵进行综述总结。结果对发酵工艺进行了总结出中药的发酵设备、发酵优化工艺、发酵菌种等,优化探索中药发酵技术;进一步明确发酵后化学成分及药效学的变化研究的梳理使其物质基础与作用机制更加明确,开发其在医学临床、畜牧业等诸多领域的应用。结论通过以药性变化、化学成分、药理作用相关研究为基础,对发酵菌种、发酵形式、发酵设备、工艺参数进行筛选,可使中药饮片更高效地达到发酵炮制作用;并通过现代微生物学的发展开拓中药新的研究领域,可推动中药发酵的炮制现代化。
Objective At present,there are some problems in the research of traditional Chinese medicine fermentation,such as unclear fermentation mechanism,backward technology and insufficient systematic quality evaluation standard.It is difficult to give full play to the curative effect of traditional Chinese medicine fermented decoction pieces,and it is difficult to achieve process standardization,uniform specifications and intelligent equipment.Therefore,it is necessary to further explore the processing methods of traditional Chinese medicine fermented decoction pieces,verify the processing principle and modernize the processing technology,so as to provide reference for the development of traditional Chinese medicine fermentation technology.Methods Through literature analysis and ancient literature review,the traditional fermentation methods of traditional Chinese medicine were verified and summarized,and the related research on the fermentation of traditional Chinese medicine was summarized.The fermentation of traditional Chinese medicine was summarized from the aspects of fermentation strains,fermentation forms,fermentation equipment,process optimization,fermentation mechanism,chemical composition change and pharmacological action change and application research.Results The fermentation process was summarized,the fermentation equipment,fermentation optimization process and fermentation strains of traditional Chinese medicine were summarized,and the fermentation technology of traditional Chinese medicine was optimized and explored.Further clarify the changes of chemical composition and pharmacodynamics after fermentation,make its material basis and mechanism of action more clear,and develop its application in many fields such as medical clinic and animal husbandry.Conclusion Based on the study of drug property change,chemical composition and pharmacological action,the fermentation strain,fermentation form,fermentation equipment and process parameters were screened to make Chinese herbal pieces achieve fermentation proce
作者
宋沁洁
李咸慰
李国峰
杨新荣
边甜甜
张育贵
孙宇靖
李越峰
SONG Qinjie;LI Xianwei;LI Guofeng;YANG Xinrong;BIAN Tiantian;ZHANG Yugui;SUN Yujing;LI Yuefeng(School of Phamacy,Gansu University of Traditional Chinese Medicine,Lanzhou 730000,China;Key Laboratory for The Study of Quality and Standards of Chinese Medicine in Gansu Province,Lanzhou 730000,China)
出处
《沈阳药科大学学报》
CAS
CSCD
2024年第10期1298-1305,共8页
Journal of Shenyang Pharmaceutical University
基金
国家自然科学基金资助项目(81960713,82160750)
甘肃省教育厅产业支撑计划项目(2021CYZC-21)
甘肃省中药制药工艺工程研究中心开放课题(ZYGY202003)
甘肃省科技计划(创新基地与人才计划)基础研究创新群体项目(21JR7RA569)。
关键词
中药
发酵
研究进展
应用
traditional Chinese medicine
fermentation
research progress
application
