摘要
精神障碍是一类行为、情绪、认知或思维紊乱的疾病,导致个体产生痛苦和社会功能障碍,是全球十大疾病负担之一。大麻二酚(cannabidiol,CBD)是大麻的主要成分之一,具有较高的安全性和耐受性,是药物研究的热点。CBD具有广泛的治疗效果,研究发现CBD具有抗成瘾、抑郁、焦虑和应激等神经精神效应,是治疗精神障碍的候选药物之一。该文总结了CBD治疗主要精神障碍的机制和临床研究进展,以期为CBD相关化合物治疗精神障碍提供有益的参考。
Mental disorders are a type of behavioral,emotional,cognitive,or thinking disorder that cause pain and social dysfunction,and are one of the top ten global disease burdens.Cannabidiol(CBD)is one of the main components of cannabis,with high safety and tolerability,and is a hot topic in drug research.CBD has a wide range of therapeutic effects,and research has found that CBD has neuropsychiatric effects such as anti-addiction,anti-depression,anti-anxiety,and anti-stress,making it one of the candidate drugs for mental disorders.This article summarizes the mechanism and research progress of CBD for major mental disorders,in order to provide useful references for CBDrelated compounds in the treatment of mental disorders.
作者
徐荟芳
况伟宏
李进
XU Huifang;KUANG Weihong;LI Jin(Mental Health Center,West China Hospital,Sichuan University,Chengdu,Sichuan 610041,P.R.China;Department of Acute Psychiatry,Chengdu Fourth People’s Hospital,Chengdu,Sichuan 610036,P.R.China)
出处
《华西医学》
CAS
2024年第10期1662-1667,共6页
West China Medical Journal
关键词
大麻二酚
精神障碍
治疗
作用机制
Cannabidiol
mental disorders
treatment
mechanisms of action
