摘要
目的分析不同表型支气管扩张症患者急性加重期的炎症水平、临床特点及预后情况。方法回顾性分析2021年1月至2023年6月在我院就诊的支气管扩张症急性加重期患者80例的临床资料,根据病因不同将患者分为非感染后支气管扩张症组(非感染组)25例,感染后支气管扩张症组(感染组)25例、特发性支气管扩张症组(特发性组)30例,观察3组患者的临床特点(咳嗽、咳痰、咯血、发热、呼吸困难、乏力、干啰音及湿啰音)、炎症指标[白介素-6(IL-6)、白介素-10(IL-10)、肿瘤坏死因子-α(TNF-α)、超敏C反应蛋白(hs-CRP)及降钙素原(PCT)]、肺功能指标[第一秒用力呼气容积(FEV1)、时间肺活量(FEV1/FVC)]及预后情况[病死率、支气管扩张症严重程度指数(BSI)评分及支气管扩张症严重程度分级评分(FACED)]情况。结果3组患者在咳嗽、咳痰、发热、乏力、湿啰音方面比较,差异均无统计学意义(P>0.05)。感染组的咯血发生率高于非感染组,乏力发生率高于特发性组(均P<0.05),非感染组的干啰音发生率高于感染组和特发性组(均P<0.05),特发性组的呼吸困难发生率低于感染组与非感染组(均P<0.05)。感染组的IL-6、TNF-α、hs-CRP及PCT水平均高于非感染组,IL-6、hs-CRP及PCT水平均高于特发性组,差异均有统计学意义(均P<0.05);非感染组的IL-10水平均高于感染组与特发性组,差异均有统计学意义(均P<0.05)。3组患者的肺功能指标比较,差异无统计学意义(均P>0.05)。感染组的BSI评分与FACED评分均高于非感染组与特发性组,感染组患者的死亡率高于非感染组与特发性组,差异均具有统计学意义(均P<0.05)。结论不同表型支气管扩张症患者急性加重期的炎症指标、BSI及FACED评分方面有所差异,感染后患者的血清炎症因子水平、BSI及FACED评分更高,可作为判断支气管扩张症病情的参考指标;在临床症状方面也有所差异,能够为区分不�
Objective To analyze the inflammatory levels,clinical characteristics,and prognosis of patients with acute exacerbation of bronchiectasis of different phenotypes.Methods A retrospective analysis of 80 patients with acute exacerbations of bronchiectasis presented from January 2021 to June 2023,Patients were divided into 25 non-infection post-infection bronchiectasis group(non-infected group),25 post-infection bronchiectasis group(infected group)and 30 idiopathic bronchiectasis group(idiopathic group),the clinical characteristics(cough,cough,cough,hemoptysis,fever,dyspnea,fatigue,dry rales and dampness),inflammation(IL-6,IL-10,IL-10,TNF-α,hs-CRP and PCT),pulmonary function(FEV1,FEV1/FEVC)and prognosis(mortality rate,BSI score,and FACED score)were observed in Group 3 patients.Results There were no significant differences in cough,sputum,fever,fatigue and moist rales among 3 groups(P>0.05).The incidence of hemoptysis in the infection group was higher than that in the non-infection group,the incidence of fatigue was higher than that in the idiopathic group(all P<0.05),the incidence of rales in the non-infection group was higher than that in the infection group and the idiopathic group(all P<0.05),the incidence of dyspnea in the idiopathic group was lower than that in the infection group and the non-infection group(all P<0.05).The levels of IL-6,TNF-α,hs-CRP and PCT in infection group were higher than those in non-infection group,and the levels of IL-6 and hs-CRP and PCT were higher than those in idiopathic group,with statistical significance(all P<0.05).The levels of IL-10 in non-infected group were higher than those in infected group and idiopathic group,with statistical significance(all P<0.05).There was no significant difference in lung function indexes among 3 groups(all P>0.05).The BSI score and FACED score in the infected group were higher than those in the non-infected and idiopathic groups,and the mortality of patients in the infected group was higher than that in the non-infected and idiopathic groups,with
作者
简勇
何成
刘阳
潘冬青
章志俊
JIAN Yong;HE Cheng;LIU Yang;PAN Dongqing;ZHANG Zhijun(Department of Respiratory and Critical Care Medicine,Xinyu People's Hospital,Xinyu City,Jiangxi Province,338000,China)
出处
《蛇志》
2024年第3期343-347,361,共6页
Journal of Snake
基金
江西省卫生健康委科技计划项目(项目名称:不同表型的支气管扩张症患者急性加重期的炎症水平、临床特点及预后分析,项目编号:202140594)。
关键词
支气管扩张症
表型
急性加重期
炎症水平
Bronchiectasia
Phenotype
Acute exacerbation period
Inflammation level
