摘要
目的观察清金贝蒌汤治疗支气管扩张症(BE)痰热壅肺型的临床疗效及对肺功能、血清炎症因子水平的影响。方法将99例BE痰热壅肺型患者按照随机数字表法分为2组,对照组49例予西医常规治疗,治疗组50例在对照组治疗基础上联合清金贝蒌汤治疗,2组均治疗1个月。比较2组疗效;观察2组治疗前后中医证候评分、肺功能指标、血清炎症因子水平、圣乔治呼吸问卷(SGRQ)评分变化;观察2组不良反应发生情况。结果治疗组总有效率98.00%(49/50),对照组总有效率85.71%(42/49),治疗组疗效优于对照组(P<0.05)。2组治疗后中医证候咳嗽咯痰、气急气促、咯血、胸闷胸痛、心烦口渴、面红目赤评分均较本组治疗前降低(P<0.05),且治疗组降低更明显(P<0.05)。2组治疗后肺功能第1 s用力呼气容积(FEV_(1))、用力肺活量(FVC)、一氧化碳弥散量占预计值百分比(DLCO%pred)均较本组治疗前升高(P<0.05),且治疗组升高更明显(P<0.05)。2组治疗后炎症因子白细胞介素6(IL-6)、IL-1β、肿瘤坏死因子α(TNF-α)水平均较本组治疗前降低(P<0.05),且治疗组降低更明显(P<0.05)。2组治疗后SGRQ活动受限、呼吸症状、疾病影响评分及总评分均较本组治疗前降低(P<0.05),且治疗组降低更明显(P<0.05)。结论清金贝蒌汤治疗BE痰热壅肺型,可改善患者中医证候及肺功能,降低血清炎症因子水平,改善呼吸状况。
Objective To observe the clinical efficacy of Qingjin Beilou Decoction for bronchiectasis(BE)of phlegm-heat obstructing lung type and how it impacts on pulmonary function and serum inflammatory factor level.Methods Totally 99 BE patients(phlegm-heat obstructing lung type)were assigned into two groups by random number table,50 cases in treatment group were treated with routine Western medicine plus Qingjin Beilou Decoction,and 49 cases in control group with routine Western medicine only.Treated for 1 month,the key observation was traditional Chinese medicine(TCM)symptom scores,pulmonary function index,serum inflammatory factor level,St George's respiratory questionnaire(SGRQ)scores,as well as adverse reactions;the curative effect was counted.Results The total effective rates were better in treatment group than in control group[98.00%(49/50)vs 85.71%(42/49),(P<0.05),respectively].After treatment,TCM symptom(cough and expectoration,shortness of breath,hemoptysis,chest tightness and chest pain,upset and thirst,blush and red eyes)scores in groups were decreased(P<0.05),which decreased notably in treatment group(P<0.05);forced expiratory volume in one second(FEV_(1)),forced vital capacity(FVC),predicted diffusing capacity of the lung for carbon monoxide(DLCO%pred)in groups were increased(P<0.05),which in treatment group were significantly increased(P<0.05);interleukin-6(IL-6),IL-1β,tumor necrosis factor-α(TNF-α)in groups were decreased(P<0.05),improvement of which in treatment group were significantly better(P<0.05);SGRQ scores including limited activity,respiratory symptoms and disease impact in groups were decreased(P<0.05),treatment group was obviously decreased in comparison with control group(P<0.05).Conclusion For BE patients(phlegm-heat obstructing lung type),Qingjin Beilou Decoction is capable of improving TCM symptoms,lung function and respiratory status,reducing serum inflammatory factor levels.
作者
傅梦清
张丽
刘丽杰
FU Mengqing;ZHANG Li;LIU Lijie(Department of Respiratory Medicine,Beijing Hospital of Traditional Chinese Medicine Shunyi Hospital,Beijing 101300;Department of Medical Affairs,Beijing Hospital of Traditional Chinese Medicine Shunyi Hospital,Beijing 101300;Department of Emergency,Dongzhimen Hospital,Beijing University of Chinese Medicine,Beijing 100700)
出处
《河北中医》
2022年第6期949-952,共4页
Hebei Journal of Traditional Chinese Medicine
关键词
支气管扩张症
中药疗法
炎症因子
肺功能
Bronchiectasis
Traditional Chinese medicine therapy
Inflammatory factors
Lung function
