摘要
目的探讨中性粒细胞与淋巴细胞比值(NLR)与支气管扩张症(支扩症)急性加重期严重程度的相关性。方法回顾性分析2016年1月—2019年4月在本院呼吸科住院治疗的支扩症患者481例,纳入符合入组条件的191例,其中男性75例,女性116例,年龄17~86岁,平均(59.23±13.34)岁。分析NLR、血红蛋白(HB)、血小板与淋巴细胞比值(PLR)、C反应蛋白(CRP)和支气管扩张严重程度(bronchiectasis severity index,BSI)以及FAECD积分的相关性;用多重线性回归分析法分别分析BSI及FACED积分的影响因素;分别根据支气管扩张严重程度(BSI)、FACED积分将入组患者分为轻、中、重组,用单因素方差分析NLR在不同组之间的差异。结果血清NLR(r=0.67)、PLR(r=0.45)、CRP(r=0.56)和BSI积分呈正相关(P值均<0.01)。血清NLR(r=0.53)、PLR(r=0.43)、CRP(r=0.45)和FACED积分呈正相关(P值均<0.01)。多重线性回归分析显示:NLR(β系数1.29,95%CI 0.95~1.72,P=0.01)、CRP(β系数1.24,95%CI 0.68~1.55,P<0.01)对BSI积分的影响均有统计学意义,NLR(β系数1.25,95%CI 0.70~1.66,P=0.02)、CRP(β系数1.20,95%CI 0.53~1.60,P=0.01)对FACED积分的影响均有统计学意义。BSI及FACED积分越高NLR水平越高,NLR分别在两种积分不同严重程度组间差别均有统计学意义(P值均<0.05)。结论NLR是预测支扩症急性加重期严重程度的有用指标。
Objective To investigate the correlation between the neutrophil/lymphocyte ratio(NLR)and the severityin acute exacerbation of bronchiectasis.Methods The data of 481 case of bronchiectasis who were hospitalized in the respi-ratory department of a hospital from January 2016 to April 2019 were retrospectively analyzed,and 191 patients with bronchi-ectasis who met the entry criteria were included into the research group,with 75 males and 116 females,and aged from 17 to86 years with the average age of(59.23±13.34)years.The correlations between the laboratory parameters,such as NLR,hemoglobin(HB),platelet/lymphocyte ratio(PLR),and C-reaction protein(CRP),bronchiectasis severity index(BSI)andFACED score were assessed,and the multiple-linear regression analysis was performed to identify variables independentlyassociated with BSI and FACED score.The included patients were divided into three groups according to BSI and FACEDscore,and the differences of NLR in different groups were analyzed by one-way ANOVA.Results The NLR(r=0.67),PLR(r=0.45),and CRP(r=0.56)were significantly positively correlated with BSI(all P<0.01).Meanwhile,NLR(r=0.53),PLR(r=0.43),and CRP(r=0.45)were also significantly positively correlated with the FACED score(all P<0.01).The multiple-linearregression analysis showed that NLR(β=1.29,95%CI 0.95-1.72,P=0.01)and CRP(β=1.24,95%CI 0.68-1.55,P<0.01)were independently associated with BSI.NLR(β=1.25,95%CI 0.70-1.66,P=0.02)and CRP(β=1.20,95%CI 0.53-1.60,P=0.01)had statistically significant effects on the FACEDscore.Moreover,the higher the BSI and FACED score,thehigher the level of NLR.The difference of NLR was statisti-cally significant between the two groups with differentseverities(all P<0.05).Conclusion NLR is a useful predictor of the severity in acute exacerbation of bronchiectasis.
作者
刘文静
张毛为
李元芹
孙宜田
张晓娇
朱洁晨
刘亚南
陈碧
LIU Wen-jing;ZHANG Mao-wei;LI Yuan-qin;SUN Yi-tian;ZHANG Xiao-jiao;ZHU Jie-chen;LIU Ya-nan;CHEN Bi(Department of Respiratory and Critical Medicine,Affiliated Hospital of Xuzhou Medical University,Xuzhou 221000,Jiangsu China)
出处
《中国校医》
2020年第10期732-734,779,共4页
Chinese Journal of School Doctor
基金
江苏省“六大人才高峰”高层次人才项目(WSN-081)。
