摘要
目的探讨采用短期胰岛素泵对老年2型糖尿病患者实施强化治疗后的临床效果。方法选取2022年1月—2023年12月沭阳中兴医院收治的98例老年2型糖尿病患者为研究对象,按治疗方法不同分组,对照组(49例)采用二甲双胍联合格列齐特进行治疗,研究组(49例)在对照组基础上,合理展开短期胰岛素泵强化治疗。比较两组胰岛功能指标(胰岛β细胞功能指数、空腹胰岛素)、血糖水平(空腹血糖、糖化血红蛋白、餐后2 h血糖)、治疗总有效率。结果治疗后,研究组胰岛β细胞功能指数高于对照组,空腹胰岛素低于对照组,差异有统计学意义(P均<0.05)。治疗后,研究组血糖水平均低于对照组,差异有统计学意义(P均<0.05)。研究组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。结论老年2型糖尿病患者合理采用短期胰岛素泵展开强化治疗,可提升患者胰岛β细胞功能,降低血糖水平。
Objective To investigate the clinical effect of intensive treatment with short-term insulin pump in elderly patients with type 2 diabetes mellitus.Methods A total of 98 elderly patients with type 2 diabetes mellitus admitted to Shuyang Zhongxing Hospital from January 2022 to December 2023 were selected as the research objects.According to different treatment methods,the control group(49 cases)was treated with metformin combined with gliclazide,and the study group(49 cases)was treated with short-term intensive insulin pump on the basis of the control group.The islet function indexes(homeostatic model assessment of isletβcell function index,fasting insulin),blood glucose level(fast-ing plasma glucose,glycated hemoglobin A1c,2-hour postprandial plasma glucose)and total effective rate of treat-ment were compared between the two groups.Results After treatment,the homeostatic model assessment of isletβcell function index of the study group was higher than that of the control group,and fasting insulin was lower than that of the control group,and the differences were statistically significant(both P<0.05).After treatment,all blood glucose levels in the study group were lower than those in the control group,and the differences were statistically significant(all P<0.05).The total effective rate of treatment in the study group was higher than that of the control group,and the difference was statistically significant(P<0.05).Conclusion In elderly patients with type 2 diabetes mellitus,the ratio-nal use of short-term insulin pump to carry out intensive treatment can improve the function of isletβcells and re-duce blood glucose level.
作者
黄莉莉
HUANG Lili(Department of Endocrinology,Shuyang Zhongxing Hospital,Shuyang 223600,Jiangsu,China)
出处
《糖尿病新世界》
2024年第12期70-73,共4页
Diabetes New World
关键词
老年2型糖尿病患者
短期胰岛素泵强化治疗
胰岛Β细胞功能
血糖水平
Elderly patients with type 2 diabetes mellitus
Short-term intensive insulin pump therapy
Isletβcell function
Blood glucose level
