摘要
脑中风是一种以脑血管缺血或出血性损伤为主要表现的神经系统疾病,也是全球死亡、伤残的主要原因之一,目前仍缺乏针对脑中风的神经保护药物。牛黄清心丸是脑中风防治指南及专家共识推荐的中成药,具有镇静、镇惊、解热等药理作用。该方含有的黄酮类、酚酸类、皂苷类等成分也有较强的药理活性,可改善中风引起的神经损伤,黄芩苷、人参皂苷等代表成分可通过作用于Kelch样ECH相关蛋白1(Keap1)、基质金属蛋白酶-9(MMP-9)、高迁移率组盒1蛋白(HMGB1)等重要靶点,参与调节Toll样受体4(TLR4)/核转录因子-κB(NF-κB)、核因子E2相关因子2(Nrf2)/血红素加氧酶-1(HO-1)和磷脂酰肌醇3-激酶(PI3K)/蛋白激酶B(Akt)等信号途径,从而干预血脑屏障破坏、氧化应激、炎症反应、凋亡和自噬等病理事件。现拟综述牛黄清心丸防治脑中风的研究现状及常见活性单体的实验药理进展,以期为牛黄清心丸的后续机理研究和中药活性单体的进一步开发提供理论支持。
Stroke is a neurological disease characterized by cerebral ischemia or hemorrhagic injury,leading to death and disability worldwide.At present,there is still a lack of neuroprotective drugs for the treatment of stroke.Niuhuang Qingxin pills are Chinese patent medicine recommended by guidelines and expert consensus for preventing and treating stroke.Studies have shown that Niuhuang Qingxin pills have sedative,anticonvulsant,antipyretic,and other pharmacological effects.Moreover,the main components,such as flavonoids,phenolic acids,and saponins,also exhibit strong pharmacological activities which can improve stroke-induced nerve damage.Studies have confirmed that representative ingredients such as baicalin and ginsenosides can interfere with multiple pathological events,including blood-brain barrier destruction,oxidative stress,inflammatory response,apoptosis,and autophagy,and the mechanisms of the essential ingredients are related to the action on important targets such as Kelch-like ECH-associated protein 1(Keap1),matrix metalloproteinase-9(MMP-9),and high-mobility group box 1(HMGB1),and involvement in the regulation of Toll-like receptor 4(TLR4)/nuclear factor-κB(NF-κB),nuclear factor E2-related factor 2(Nrf2)/heme oxygenase-1(HO-1),and phosphoinositide 3-kinase(PI3K)/protein kinase B(Akt)signaling pathways.This article summarized the research status of Niuhuang Qingxin pills and the experimental pharmacological progress of common ingredients in the prevention and treatment of stroke to provide clues for further research into Niuhuang Qingxin pills and the development of active ingredients of traditional Chinese medicines.
作者
张米玲
包亮英
代玉洁
宫帅帅
寇俊萍
ZHANG Miling;BAO Liangying;DAI Yujie;GONG Shuaishuai;KOU Junping(Jiangsu Key Laboratory of Traditional Chinese Medicine Evaluation and Translational Research,Department of Pharmacology of Chinese Materia Medica,School of Traditional Chinese Pharmacy,China Pharmaceutical University,Nanjing 211198,China)
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2024年第18期251-259,共9页
Chinese Journal of Experimental Traditional Medical Formulae
基金
中国药科大学“双一流”创新团队项目(CPU2018GF07)。
关键词
牛黄清心丸
卒中
脑缺血
脑出血
活性成分
Niuhuang Qingxin pills
stroke
cerebral ischemia
intracerebral hemorrhage
active ingredients
