摘要
目的:分析321例人乳头瘤病毒(HPV)感染女性患者亚型分布及宫颈病变情况。方法:回顾性纳入2021年1月至2022年12月本院就诊的321例HPV感染女性患者作为研究对象,统计患者的临床资料。所有HPV感染患者均完成宫颈组织病理学检查。统计321例HPV感染患者的分布情况,分析HPV亚型与宫颈病变情况,宫颈病变的年龄分布情况,高危与仅低危HPV感染患者宫颈病变情况,单一与多重感染HPV感染女性宫颈病变情况。结果:检测结果显示,321例HPV感染患者中,单一感染有227例(70.72%)、多重感染有94例(29.28%);高危HPV感染有289例(90.03%)、仅低危HPV感染有32例(9.97%);无宫颈病变有74例(23.05%)、低级别病变有207例(64.49%)、高级别病变有37例(11.53%)、宫颈癌有3例(0.93%);<25岁有86例(26.79%)、25~34岁有154例(47.98%)、35~44岁有81例(25.23%)。在低级别病变患者中,检出率较高的HPV亚型有HPV52、HPV16、HPV18、HPV81;在高级别病变患者中,检出率较高的HPV亚型有HPV16、HPV52、HPV58、HPV18;在宫颈癌患者中,检出率较高的HPV亚型有HPV18。宫颈病变患者年龄主要分布于25~34岁。相较于仅低危HPV组患者,高危HPV组发生高级别病变、宫颈癌的患者占比较高,但无统计学差异(P>0.05)。单一组、多重组发生低级别病变、高级别病变、宫颈癌的患者占比经比较均无差异(P>0.05)。结论:在HPV感染女性患者中HPV亚型分布不一;在不同宫颈病变级别中常见的HPV亚型有HPV52、HPV16、HPV18等,且高危HPV患者发生高级别病变、宫颈癌的风险更高,25~34岁的HPV感染患者发生宫颈病变的风险更高。
Objective:To analyze the subtype distribution and cervical lesions of 321 female patients infected with human papillomavirus(HPV).Methods:321 cases of female patients with HPV infection in our hospital from January 2021 to December 2022 were retrospectively included as the research object,and the clinical data of the patients were counted.All patients with HPV infection completed cervical histopathological examination.The distribution of in 321 patients with HPV infection was statistically analyzed.The results of HPV subtypes and cervical histopathological examination,the age distribution of cervical histopathological examination results,and the results of cervical histopathological examination in patients with high-risk and low-risk HPV infection were analyzed,cervical lesions in women with single and multiple HPV infections.Results:Among the 321 patients with HPV infection,227 cases(70.72%)had single infection and 94 cases(29.28%)had multiple infections.There were 289 cases(90.03%)of high-risk HPV infection and 32 cases(9.97%)of low-risk HPV infection.There were 74 cases(23.05%)without cervical lesions,207 cases(64.49%)with low-grade lesions,37 cases(11.53%)with high-grade lesions,and 3 cases(0.93%)with cervical cancer.There were 86 cases(26.79%)aged<25 years,154 cases(47.98%)aged 25~34 years,81 cases(25.23%)aged 35~44 years.In patients without cervical lesions,the detection rate of high HPV subtypes were HPV52,HPV51,HPV16;in patients with low-grade lesions,HPV subtypes with higher detection rates were HPV52,HPV16,HPV18,and HPV81;in patients with high-grade lesions,HPV subtypes with higher detection rates were HPV16,HPV52,HPV58,and HPV18;in patients with cervical cancer,the higher detection rate of HPV subtypes were HPV18.The age distribution of patients with cervical lesions was mainly 25~34 years old.Compared with patients of the low-risk HPV group,the proportion of patients with high-grade lesions,and cervical cancer of the high-risk HPV group were higher,but there was no difference(P>0.05).There was no diff
作者
王苗
刘偲
Wang Miao;Liu Cai(The Second People's Hospital of Jiangmen City,Guangdong Province,Jiangmen Guangdong,529000,China;Guangdong Jiangmen Chinese Medicine College,Jiangmen Guangdong,529000,China)
出处
《中外女性健康研究》
2024年第8期4-7,共4页
Women＇s Health Research
关键词
人乳头瘤病毒
宫颈病变
基因分型
Human papillomavirus
Cervical cell lesions
Genotyping
