摘要
目的:探究女性宫颈人乳头状瘤病毒(HPV)感染情况及型别分布,为本地区HPV感染和宫颈癌防治提供参考。方法:收集2019年6月-2020年6月在本院体检中心体检的女性1246例临床资料,常规获取标本PCR扩增及免疫杂交技术检测HPV感染情况。结果:在1246例中HPV感染阳性率17.7%,以单一亚型感染和二重亚型感染占比最多;在HPV感染者中,以高危亚型HPV52型、58型、16型、53型等感染占比最多;不同年龄段及不同宫颈病变者HPV感染情况存在差异(P<0.05);老龄、吸烟、初次性交年龄早、性伴侣个数及性生活频率多、阴道宫颈炎症及宫颈癌家族史、宫颈病变是高危型HPV感染的重要影响因素(P<0.05)。结论:本次调查的女性人群HPV感染率以高危亚型单一感染及双重感染居多,提示当地应积极开展针对性的防高危型HPV感染及宫颈癌防治工作。
Objective:To investigate the infection status and genotype distribution of human papilloma virus(HPV)of women,and to provide reference for the prevention and treatment of HPV infection and cervical cancer.Methods:The clinical data of 1246 women who received physical examinations in the physical examination center from June 2019 to June 2020 were collected.The HPV infection situations of these women were detected by the routine obtained specimens,PCR amplification,and immune hybridization technology.Results:The HPV positive rate of these 1246 women was 17.7%,and the single genotype HPV infection rate and the double genotype HPV infection rate accounted for the highest.The proportion of high-risk genotype HPV infection,such as 52,58,16,and 53,of the women was highest.There was significant different in the HPV infection situation among the women with different age or among the women with different cervical lesions(P<0.05).Aging,smoking,less years old of the first sexual intercourse,number of sexual partners,more frequency of sexual intercourse,vaginal and cervical inflammation,family history of cervical cancer,and cervical lesions of the women were the important factors influencing their high-risk HPV infection(P<0.05).Conclusion:The HPV infection rate of the single or dual high-risk genotype infection of the women is relatively high in this survey,which suggests that the targeted prevention of high-risk HPV infection,and prevention and treatment of cervical cancer should be actively carried out.
作者
倪换娟
徐彦文
陈晓翠
裴丽鹂
NI Huanjuan;XU Yanwen;CHEN Xiaocui;PEI Lili(Heping Branch of General Hospital of Northern Theater Command, Shenyang, Liaoning Province, 110000)
出处
《中国计划生育学杂志》
2022年第1期193-197,共5页
Chinese Journal of Family Planning
关键词
人乳头状瘤病毒
高危型
宫颈癌
感染分布
影响因素
Human papilloma virus
High-risk genotype
Cervical cancer
Distribution of infection
Influence factor
