摘要
目的探讨血管内皮生长因子(VEGF)、胰岛素样生长因子1(IGF1)、神经调节蛋白1(NRG1)与首发精神分裂症患者MATRICS公认认知成套测验(MCCB)及阳性与阴性症状量表(PANSS)评分的相关性。方法回顾性选取2021年9月至2023年1月该院收治的71例首发精神分裂症患者为研究组,并选取同期进行体检的71例健康志愿者为对照组。同时,根据PANSS评分结果将研究组分为高分亚组(≥70分,33例)和低分亚组(<70分,38例);根据MCCB评分结果将研究组分为认知功能障碍组(29例)和认知功能正常组(42例)。比较各组血清VEGF、IGF1、NRG1水平,并分析其与MCCB、PANSS评分的相关性。结果研究组血清VEGF、IGF1、NRG1水平低于对照组,差异有统计学意义(P<0.05)。认知功能障碍亚组血清VEGF、IGF1、NRG1水平低于认知功能正常亚组,差异有统计学意义(P<0.05)。低分亚组血清VEGF、IGF1、NRG1水平高于高分亚组,差异有统计学意义(P<0.05)。血清VEGF、IGF1、NRG1水平分别与MCCB、PANSS评分呈正相关(P<0.05)。结论精神分裂症患者血清VEGF、IGF1、NRG1水平较健康人群低,其与精神症状、认知功能密切相关。
Objective To explore the effects of vascular endothelial growth factor(VEGF),insulin-like growth factor 1(IGF-1)and neuromodulatory protein 1(NRG1)on first-episode schizophrenia patients.Methods A total of 71 patients with first-episode schizophrenia admitted to the hospital from September 2021 to January 2023 were retrospectively selected as the study group,and 71 healthy volunteers who underwent physical examination during the same period were selected as the control group.At the same time,according to the results ofpositive and negative symptom scale(PANSS)score results,the study group was divided into the high score subgroup(≥70 points,33 cases)and the low score subgroup(<70 points,38 cases).The study group was divided into cognitive dysfunction group(29 cases)and normal cognitive function group(42 cases)according to the results of MATRICS recognized cognitive battery(MCCB).The levels of serum VEGF,IGF1,and NRG1 in each group were compared,and their correlation with MCCB and PANSS scores was analyzed.Results The levels of serum VEGF,IGF1,and NRG1 in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).The levels of serum VEGF,IGF1,and NRG1 in the cognitive dysfunction subgroup were lower than those in the normal cognitive function subgroup,and the differences were statistically significant(P<0.05).The levels of serum VEGF,IGF1,and NRG1 in the low score subgroup were higher than those in the high score subgroup,and the differences were statistically significant(P<0.05).The levels of serum VEGF,IGF1,and NRG1 were positively correlated with MCCB and PANSS scores(P<0.05).Conclusion The levels of serum VEGF,IGF1 and NRG1 in patients with schizophrenia are lower than those in healthy people,which are closely related to mental symptoms and cognitive function.
作者
刘胜超
侯瑞
LIU Shengchao;HOU Rui(Department of Psychiatry,Zhengzhou Eighth People′s Hospital,Zhengzhou,Henan 450000,China)
出处
《现代医药卫生》
2024年第15期2579-2581,2587,共4页
Journal of Modern Medicine & Health
关键词
血管内皮生长因子
胰岛素样生长因子1
神经调节蛋白1
首发精神分裂症
Vascular endothelial growth factor
Insulin-like growth factor 1
Neuroregulatory protein 1
First-episode schizophrenia
