摘要
目的:探讨内镜序贯治疗肝硬化合并食管静脉曲张出血(EVB)的效果。方法:选取2020年1月—2023年4月揭阳市人民医院收治的肝硬化合并EVB患者80例为研究对象,随机分为序贯组和常规组,各40例。常规组采用单纯食管静脉曲张套扎术(EVL)治疗,序贯组采用EVL内镜序贯治疗。比较两组临床疗效、门静脉及脾静脉血流量、并发症发生率、再出血率及复发率。结果:序贯组治疗总有效率高于常规组,差异有统计学意义(P=0.043)。术后12个月,两组门静脉、脾静脉血流量低于首次套扎后,序贯组低于常规组,差异有统计学意义(P<0.05)。序贯组并发症发生率低于常规组,差异有统计学意义(P=0.043)。术后1个月,两组均无再出血;术后3个月,两组再出血率比较,差异无统计学意义(P>0.05);术后6、12个月,序贯组再出血率低于常规组,差异有统计学意义(P<0.05)。术后1个月,两组均无复发;术后3个月,两组复发率比较,差异无统计学意义(P>0.05);术后6、12个月,序贯组复发率低于常规组,差异有统计学意义(P<0.05)。结论:内镜序贯治疗肝硬化合并EVB的效果确切,可有效控制出血量,减少再复发及再出血,减少并发症,安全性较高。
Objective:To investigate the effect of sequential endoscopic treatment of liver cirrhosis complicated with esophageal variceal bleeding(EVB).Methods:A total of eighty patients with liver cirrhosis complicated with EVB admitted to Jieyang People's Hospital from January 2020 to April 2023 were selected as the study objects and randomly divided into sequential group and routine group,with forty patients in each group.The routine group was treated with simple esophageal varices ligation(EVL),and the sequential group was treated with EVL endoscopic sequential therapy.The clinical efficacy,portal vein and splenic vein blood flow,complication rate,rebleeding rate and recurrence rate were compared between the two groups.Results:The total effective rate of the sequential group was higher than that of the routine group,the difference was statistically significant(P=0.043).Twelve months after surgery,the blood flow of portal vein and spleen vein in two groups was lower than that after the first ligation,and that in the sequential group was lower than that in the routine group,the difference was statistically significant(P<0.05).The incidence of complications in sequential group was lower than that in routine group,and the difference was statistically significant(P=0.043).One month after operation,there was no rebleeding in both groups;three months after operation,there was no significant difference in rebleeding rate between the two groups(P>0.05);at 6 and 12 months after operation,the rebleeding rate in the sequential group was lower than that in the routine group,and the difference was statistically significant(P<0.05).One month after operation,there was no recurrence in both groups;three months after operation,there was no significant difference in recurrence rate between the two groups(P>0.05);at 6 and 12 months after operation,the recurrence rate of the sequential group was lower than that of the routine group,and the difference was statistically significant(P<0.05).Conclusion:Endoscopic sequential treatment of liver c
作者
陈锐沛
袁楚明
陈世勇
孙旭锐
Chen Ruipei;Yuan Chuming;Chen Shiyong;Sun Xurui(Department of Gastroenterology,Jieyang People's Hospital,Jieyang 522095,Guangdong Province,China)
出处
《中外医药研究》
2024年第20期75-77,共3页
JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH
基金
揭阳市医学科学技术研究项目(编号:20220625)。
关键词
肝硬化
食管静脉曲张出血
内镜套扎术
内镜序贯治疗
Liver cirrhosis
Esophageal varices bleeding
Endoscopic ligation
Endoscopic sequential therapy
