摘要
目的探讨宫颈环形电切术治疗宫颈癌患者对其血清基质金属蛋白酶-9(MMP-9)、瘦素水平及宫颈癌复发率的影响。方法选取2020年1月至2022年9月常德市妇幼保健院收治的200例宫颈癌患者作为研究对象,随机分为观察组和对照组,每组100例。观察组采用宫颈环形电切术治疗,对照组采用冷刀锥切术治疗;比较两组围手术期指标、并发症发生率、复发率、视觉模拟评分法(VAS)评分;比较两组血清应激因子、免疫球蛋白、MMP-9及瘦素水平。结果治疗后观察组术中出血量少于对照组,住院时间、排气时间短于对照组,淋巴清扫数大于对照组,差异具有统计学意义(P<0.05)。观察组术后复发率低于对照组,差异具有统计学意义(P<0.05)。治疗后观察组免疫球蛋白A(IgA)、免疫球蛋白G(IgG)及免疫球蛋白M(IgM)水平显著高于对照组,生长激素(GH)、皮质醇(Cor)、血管紧张素Ⅱ(AngⅡ)、MMP-9及瘦素水平显著低于对照组,差异具有统计学意义(P<0.05)。术后1 d、术后1周,观察组VAS评分显著低于对照组,差异具有统计学意义(P<0.05)。术后1年内观察组复发率低于对照组,差异具有统计学意义(P<0.05)。结论宫颈癌患者采用宫颈环形电切术治疗,可有效降低血清MMP-9、瘦素、应激因子水平,提升免疫球蛋白水平,围手术期指标好,复发率低,安全性好。
Objective To explore the effects of cervical cerclage electrosurgery for the treatment of cervical cancer patients on their serum matrix metalloproteinase-9(MMP-9),leptin levels and cervical cancer recurrence rate.Methods A total of 200 cases of cervical cancer patients admitted to Changde Maternal and Child Health Hospital from January 2020 to September 2022 were selected as the study subjects,and randomly divided into the observation group and the control group,with 100 cases in each group.The observation group was treated with cervical cerclage electrosurgery,and the control group was treated with cold knife conization.The perioperative indexes,complication rate,recurrence rate,and visual analog scale(VAS)score of the two groups were compared;and the levels of serum stress factors,immunoglobulin,MMP-9 and leptin of the two groups were compared.Results After treatment,intraoperative bleeding in the observation group was less than that in the control group,hospital stay and exhaust time were shorter than those in the control group,and the number of lymphatic clearance number was greater than that in the control group,and the differences were statistically significant(P<0.05).The postoperative recurrence rate of the observation group was lower than that of the control group,and the difference was statistically significant(P<0.05).The levels of immunoglobulin A(IgA),immunoglobulin G(IgG)and immunoglobulin M(IgM)in the observation group were significantly higher than those in the control group after treatment,and the levels of growth hormone(GH),cortisol(Cor),angiotensinⅡ(AngⅡ),MMP-9 and leptin were significantly lower than those in the control group,with statistically significant differences(P<0.05).The VAS score of the observation group was significantly lower than that of the control group at 1 d and 1 week postoperatively,and the differences were statistically significant(P<0.05).The recurrence rate of the observation group was lower than that of the control group in 1 year after operation,and the differenc
作者
邵华萍
石冬妮
覃明辉
钟晓英
SHAO Huaping;SHI Dongni;QIN Minghui;ZHONG Xiaoying(Department of Gynecology,Changde Matemal and Child Health Hospital,Changde 415101,Hunan,China;Department of Gynecology,Dingcheng Maternal and Child Health Hospital,Changde 415100,Hunan,China;Department of Obstetrics and Gymecology,Linli County People's Hospital,Changde 415129,Hunan,China)
出处
《中国性科学》
2024年第7期52-56,共5页
Chinese Journal of Human Sexuality
基金
湖南省卫生健康委2023年度卫生科研课题项目(D202305028123)。
关键词
基质金属蛋白酶-9
瘦素
宫颈环形电切术
宫颈癌
复发
Matrix metalloproteinase-9
Leptin
Cervical cerclage electrosurgery
Cervical cancer
Recurrence
