摘要
帕金森病(PD)多发于老年人群,随着病情逐渐进展,对PD患者的运动功能和非运动功能影响巨大。目前PD的主要治疗是药物治疗,但长期服用会产生不良反应,寻找更安全有效的治疗方法十分必要。微生物-脑-肠轴(MGBA)是连接中枢神经系统与消化系统的通道,在PD发病机制中发挥重要作用。文章主要就肠道菌群、脑肠肽和下丘脑-垂体-肾上腺轴对PD的影响,以及基于MGBA理论对PD的治疗现状等进行综述。
Parkinson's disease(PD)is more common in the elderly,and with the gradual progression of the disease,the motor function and non-motor function of PD patients are greatly affected.At present,the main treatment for PD is drug therapy,but long-term use will cause adverse reactions,so it is necessary to find safer and more effective treatment methods.The microbial-brain-gut axis(MGBA)is a pathway connecting the central nervous system and the digestive system,and plays an important role in the pathogenesis of PD.This article mainly reviews the effects of intestinal flora,brain-intestinal peptide and hypothalamic-pituitary-adrenal axis on PD,and the current treatment status of PD based on MGBA theory.
作者
赵雨欣
王亚辉
李杰(综述)
邢军(审校)
ZHAO Yuxin;WANG Yahui;LI Jie;XING Jun(Department of Rehabilitation Medicine,The First Hospital of Hebei Medical University,Shijiazhuang 050000,Hebei,China)
出处
《医学研究与战创伤救治》
CAS
北大核心
2024年第4期433-438,共6页
Journal of Medical Research & Combat Trauma Care
基金
河北省中医药管理局2022年度中医药类科研计划课题(Z2022016)。
关键词
帕金森
微生物-脑-肠轴
肠道微生物
针刺
神经调控技术
益生菌
粪菌移植
Parkinson's disease
microbial-gut-brain axis
enteric microorganisms
acupuncture
neurore-gulatory techniques
probiotics
fecal microbiota transplantation
