摘要
乳腺癌是女性常见的恶性肿瘤之一,其发病率和死亡率呈逐年上升趋势。目前治疗乳腺癌的大多数药物会产生一些不良反应。植物多糖具有多种生物活性,可通过抑制细胞增殖、抑制细胞迁移和侵袭、诱导细胞凋亡、调节细胞周期、抑制肿瘤血管生成、免疫调节、抗氧化等途径抗乳腺癌。综述了植物多糖抗乳腺癌的作用机制研究进展,为植物多糖开发抗乳腺癌新药提供参考。
Breast cancer is one of the most common malignant tumors in women,and its incidence rate and mortality are increasing year by year.At present,most of drugs for breast cancer will produce some adverse reactions.Plant polysaccharides have a variety of biological activities.They have anti-breast cancer effect by inhibiting cell proliferation,inhibiting cell migration and invasion,inducing apoptosis,regulating cell cycle,inhibiting tumor angiogenesis,immune regulation,antioxidant and other ways.This article reviews the research progress on the mechanism of plant polysaccharides against breast cancer,providing reference for the development of plant polysaccharides as new drugs against breast cancer.
作者
杨紫焰
李倩倩
张翠香
陈贵元
YANG Ziyan;LI Qianqian;ZHANG Cuixiang;CHEN Guiyuan(School of Basic Medical Sciences,Dali University,Dali 671000,China;Yunnan Provincial Key Laboratory of Entomology Biopharmaceutical R&D,Dali 671000,China)
出处
《现代药物与临床》
CAS
2024年第5期1343-1347,共5页
Drugs & Clinic
基金
国家自然科学基金地区项目(31860252)
云南省自然科学基金地方高校联合面上项目(202301BA070001-043)
云南省昆虫生物医药研发重点实验室开放项目(AG2022006)。
关键词
植物多糖
乳腺癌
细胞增殖
细胞迁移和侵袭
细胞凋亡
细胞周期
肿瘤血管生成
免疫调节
抗氧化
plant polysaccharides
breast cancer
cell proliferation
cell migration and invasion
cell apoptosis
cell cycle
tumor angiogenesis
immune regulation
antioxidant
