摘要
目的探究柴银亚甲方联合常规西药治疗亚急性甲状腺炎患者的临床疗效及安全性。方法选取2021年1月—2021年12月期间唐山市中医医院收治的亚急性甲状腺炎患者90例作为研究对象,依据简单随机数字表法分为对照组和研究组,每组各45例。对照组采用常规西药治疗,研究组在对照组基础上加用柴银亚甲方。治疗3个月后,观察比较两组患者临床疗效、不良反应及疾病复发率,治疗前后中医证候积分、血沉(Erythrocyte sedimentation rate,ESR)及甲状腺功能指标[促甲状腺激素(Thyroid stimulating hormone,TSH)、游离甲状腺素(Free thyroxine,FT4)、游离三碘甲状腺原氨酸(Free triiodothyronine,FT3)]、炎症因子[干扰素-γ(Interferon-gamma,IFN-γ)、肿瘤坏死因子-α(Tumor necrosis factor-α,TNF-α)、白细胞介素-6(Interleukin-6,IL-6)]。结果治疗后研究组临床总有效率93.33%(42/45)高于对照组77.78%(35/45),差异有统计学意义(P<0.05)。治疗后两组患者发热、颈前区疼痛、颈前区肿大、乏力、震颤、多汗、烦躁易怒、心悸分值均较治疗前降低,差异有统计学意义(P<0.05);且研究组发热、颈前区疼痛、颈前区肿大、乏力、震颤、多汗、烦躁易怒、心悸分值均明显低于对照组,差异有统计学意义(P<0.05)。治疗后两组患者TSH水平均较治疗前升高,FT4、FT3及ESR水平均较治疗前降低,差异有统计学意义(P<0.05);且研究组TSH水平明显高于对照组,FT4、FT3及ESR水平均明显低于对照组,差异有统计学意义(P<0.05)。治疗后两组患者血清炎症因子IFN-γ、TNF-α、IL-6水平均较治疗前降低,差异有统计学意义(P<0.05);且研究组血清炎症因子IFN-γ、TNF-α、IL-6水平均明显低于对照组,差异有统计学意义(P<0.05)。治疗期间,研究组不良反应发生率4.44%(2/45)与对照组8.89%(4/45)比较,差异无统计学意义(P>0.05)。随访3个月,研究组疾病复发率2.22%(1/45)明显低于对照组15.56%(7/45)
Objective To explore the clinical efficacy and safety of Chaiyin Yajia Formula combined with conventional western medicine in the treatment of subacute thyroiditis.Methods Ninety patients with subacute thyroiditis treated at Tangshan Hospital of Traditional Chinese Medicine between January 2021 and December 2021 were selected and randomly divided into a control group and a study group according to a simple random number table,with 45 patients in each group.The control group received conventional western medicine,while the study group received Chaiyin Yajia Formula in addition to the conventional treatment,both for a duration of three months.The clinical efficacy,adverse reactions,and disease recurrence rates were observed and compared between the two groups.Additionally,the traditional Chinese medicine(TCM)symptom scores,erythrocyte sedimentation rate(ESR),thyroid function indicators[thyroid stimulating hormone(TSH),free thyroxine(FT4),and free triiodothyronine(FT3)],and inflammatory factors[interferon-gamma(IFN-γ),tumor necrosis factor-alpha(TNF-α),and interleukin-6(IL-6)]were evaluated before and after treatment.Results After treatment,the overall clinical efficacy in the study group was 93.33%(42/45),higher than 77.78%(35/45)in the control group(P<0.05).The scores for symptoms such as fever,anterior neck pain,anterior neck swelling,fatigue,tremors,excessive sweating,irritability,and palpitations were significantly lower in both groups after treatment(P<0.05),and the study group showed significantly lower scores than the control group(P<0.05).Post-treatment,TSH levels increased,while FT4,FT3,and ESR levels decreased significantly in both groups(P<0.05);the study group showed significantly higher TSH levels and lower FT4,FT3,and ESR levels than the control group(P<0.05).Inflammatory factors IFN-γ,TNF-α,and IL-6 levels also decreased significantly in both groups after treatment(P<0.05),with the study group showing significantly lower levels than the control group(P<0.05).During the treatment period,the incide
作者
高阎满
曹宏叶
孙佳佳
张军
GAO Yan-man;CAO Hong-ye;SUN Jia-jia;ZHANG Jun(Department of Geriatrics,Tangshan Hospital of Traditional Chinese Medicine,Tangshan Hebei 063021;Department of Internal Medicine,Fengnan District Hospital of Traditional Chinese Medicine,Tangshan Hebei 063021;Department of Endocrinology I,Tangshan Hospital of Traditional Chinese Medicine,Tangshan Hebei 063021)
出处
《世界中西医结合杂志》
2024年第6期1212-1217,共6页
World Journal of Integrated Traditional and Western Medicine
基金
河北省中医药管理局项目(2021400)。
关键词
柴银亚甲方
常规西药
亚急性甲状腺炎
甲状腺功能
炎症因子
Chaiyin Yajia Formula
Conventional Western Medicine
Subacute Thyroiditis
Thyroid Function
Inflammatory Factor
