摘要
目的:观察黄芩清热除痹胶囊治疗类风湿关节炎的临床疗效及对血清M1、M2型炎症因子的影响。方法:将60例类风湿关节炎(RA)患者采用随机数字对照分成研究组和对照组,每组各30例。研究组和对照组均予基础治疗,研究组在此基础上服用黄芩清热除痹胶囊,每次3粒口服,每日3次,两组的疗程均为4 w。比较两组临床疗效、中医证候积分、28处关节疾病活动度评估(28-joint disease activity score,DAS28)、类风湿因子(rheumatoid factor,RF)、C反应蛋白(c-reactive protein,CRP)、血沉(erythrocyte sedimentation Rate,ESR)、VAS疼痛评分(visual analogue score,VAS)、M1型细胞因子(interleukin-1,IL-1β、interleukin-6,IL-6、tumor necrosis factor-α,TNF-α)和M2型细胞因子(interleukin-4,IL-4、interleukin-10,IL-10)。结果:研究组总有效率(96.6%)明显高于对照组(70.0%)(P<0.05);与治疗前比较,研究组治疗后关节发热评分、汗出评分、口渴评分、大便干结评分、DAS28、VAS、ESR、CRP、RF、IL-6、IL-1β、TNF-α均明显降低(P<0.05),IL-4、IL-10含量明显升高(P<0.05);对照组治疗后关节发热评分、汗出评分、DAS28、VAS、ESR、CRP、RF、IL-6、IL-1β、TNF-α均明显降低(P<0.05),IL-4、IL-10含量明显升高(P<0.05);与对照组治疗后比较,研究组治疗后关节发热评分、汗出评分、口渴评分、大便干结评分、DAS28、RF、IL-1β明显降低(P<0.05),IL-4含量明显升高(P<0.05)。结论:黄芩清热除痹胶囊联合基础疗法能够有效改善RA患者临床症状,通过降低M1型细胞因子,升高M2型细胞因子来抑制炎症反应,改善关节症状,提高临床疗效。
Objective:To observe the clinical efficacy of Huangqin Qingre Chubi(黄芩清热除痹)Capsules(HQC)in the treatment of rheumatoid arthritis(RA)and the effects on serum M1 and M2 inflammatory factors.Methods:Sixty patients with RA were randomly divided into an observation group and a control group according to a random number table,with 30 cases in each group.All patients received basic treatment,while those in the observation group were treated with additional HQC by oral administration,3 capsules per time,3 times a day.The treatment course of both groups was 4 weeks.The clinical efficacy,traditional Chinese medicine(TCM)syndrome score,disease activity score in 28 joints(DAS28),rheumatoid factor(RF),C-reactive protein(CRP),erythrocyte sedimentation rate(ESR),visual analogue score(VAS),M1-cytokines[interleukin(IL)-1β,IL-6,and tumor necrosis factor-α(TNF-α)],and M2 cytokines(IL-4 and IL-10)were compared between the two groups.Results:The total effective rate of the observation group was 96.6%,higher than 70.0%of the control group(P<0.05).In the observation group,the post-treatment TCM syndrome scores(joint fever,sweating,thirst,and dry stool),DAS28,VAS,ESR,CRP,RF,IL-6,IL-1β,and TNF-αwere lower(P<0.05),while the content of IL-4 and IL-10 was higher than those before treatment(P<0.05).In the control group,the post-treatment joint fever score,sweating score,DAS28,VAS,ESR,CRP,RF,IL-6,IL-1β,and TNF-αwere lower(P<0.05)and the content of IL-4 and IL-10 was higher than those before treatment(P<0.05).After treatment,compared with the control group,the observation group showed reduced joint fever score,sweating score,thirst score,dry stool score,DAS28,RF,and IL-1β(P<0.05),and increased IL-4(P<0.05).Conclusion:HQC combined with basic therapy can effectively improve the clinical symptoms of RA patients and suppress inflammatory response by reducing the expression of M1 cytokines and increasing the expression of M2 cytokines to improve joint symptoms and clinical efficacy.
作者
李舒
万磊
赵磊
汤忠富
孙广瀚
朱子衡
马熙檬
吴彦
Li Shu;Wan Lei;Zhao Lei;Tang Zhongfu;Sun Guanghan;Zhu Ziheng;Ma Ximeng;Wu Yan(Graduate School of Anhui University of Chinese Medicine,Hefei 230031;Department of Rheumatology,The First Affiliated Hospital of Anhui University of Chinese Medicine,Hefei 230031;Anhui University of Chinese Medicine,Hefei 230031)
出处
《中药药理与临床》
CAS
CSCD
北大核心
2022年第2期190-194,共5页
Pharmacology and Clinics of Chinese Materia Medica
基金
国家自然基金面上项目(编号:81973655)
安徽省高校自然科学研究项目(编号:KJ2020A0397)
科技部国家重点研发计划中医药现代化研究重点专项(编号:2018YFC1705204)
全国中医药创新骨干人才培训项目(国中医药人教函[2019]128号)
安徽中医药大学校基金项目(编号:2018xrxd17)
安徽中医药大学第一附属医院院内基金(编号:2020yfyzc25、2020yfyzc55)
关键词
黄芩清热除痹胶囊
类风湿关节炎
巨噬细胞
炎症极化
炎症因子
Huangqin Qingre Chubi(黄芩清热除痹)Capsules
rheumatoid arthritis
macrophage
inflammatory polarization
inflammatory factors
