摘要
目的:探讨维生素D联合肠内营养支持对肝硬化伴食管胃底静脉出血患者肝功能、营养状况、预后的影响。方法:招募自2023年1月—2023年12月在我院住院治疗的肝硬化伴食管胃底静脉出血的100例患者,采用随机数字表随机分为维生素D联合肠内营养干预组(干预组)和对照组,对照组患者给予常规治疗和干预,干预组患者在此基础上,给予维生素D和肠内营养干预,比较两组患者干预前后肝功能指标、营养指标的变化,以及胃肠道反应、再出血发生率、住院时间差异。结果:两组患者经干预后,血清肝功能指标(ALT、AST、GGT)均较干预前下降,血清营养指标(PA、TP、ALB)均较干预前增高,差异有统计学意义(P<0.05),且干预后,干预组患者肝功能和蛋白营养状况改善情况均优于对照组,差异有统计学意义(P<0.05)。干预组患者不良胃肠道反应发生率为8%,显著低于对照组(发生率为32%,χ^(2)=9.000,P=0.003)。干预组患者再出血发生率显著低于对照组(4%vs 16%,P=0.046)。干预组患者平均住院时间显著低于对照组[(11.00±2.222)vs(15.90±1.418)d,P<0.001]。结论:维生素D联合肠内营养支持对肝硬化伴食管胃底静脉曲张出血患者肝功能具有改善作用,且可改善患者蛋白营养状况,减少不良胃肠道反应发生率、再出血发生率和住院时间,值得在临床推广应用。
【Objective】To exploring the effects of vitamin D combined with enteral nutritional support on liver function,nutritional status,and prognosis of patients with liver cirrhosis with oesophagogastric fundus vein haemorrhage.【Method】Totally 100 patients with liver cirrhosis with oesophagogastric fundal vein bleeding who were hospitalised in our hospital from January 2023 to December 2023 were collected and randomly divided into the vitamin D combined enteral nutrition intervention group(observation group)and the control group using a random number table,and the control group was given conventional treatment and intervention,while the observation group patients were given vitamin D and enteral nutrition intervention on top of it,and the intervention of the patients of the two groups was compared.Changes in liver function indexes and nutritional indexes before and after the intervention,as well as the differences in gastrointestinal reactions,incidence of rebleeding,and hospitalisation time.【Result】After the intervention,the serum liver function indexes(ALT,AST and GGT)of the two groups of patients decreased compared with the pre-intervention period,and the serum nutritional indexes(PA,TP and ALB)increased compared with the pre-intervention period,and the difference was statistically significant(P<0.05),and the improvement of the liver function and nutritional status of the patients in the observation group was better than that of the control group after the intervention,and the difference was statistically significant(P<0.05).The incidence of adverse gastrointestinal reactions in the observation group was 8%,which was significantly lower than that in the control group(incidence of 32%,χ^(2)=9.000,P=0.003).The incidence of rebleeding was significantly lower in the observation group than in the control group(4%vs 16%,P=0.046).The mean length of stay in the observation group was significantly lower than that in the control group[(11.00±2.222)days vs.(15.90±1.418)days,P<0.001].【Conclusion】Vitamin D comb
作者
廖中宝
李彬
李茂章
雷勇
侯能易
LIAO Zhong-bao;LI Bin;LI Mao-zhang;LEI Yong;HOU Neng-yi(General Surgery Department of Sichuan Friendship Hospital,Chengdu 610000,China;Gastroenterology Department of Sichuan Provincial People's Hospital,Chengdu 610000,China)
出处
《中国食物与营养》
2024年第6期81-85,共5页
Food and Nutrition in China
基金
四川省科技计划项目(项目编号:2023YFS0197)。
关键词
维生素D
肠内营养
肝硬化食管胃底静脉出血
肝功能
蛋白营养状况
预后
vitamin D
enteral nutrition
oesophagogastric fundal vein haemorrhage in cirrhosis
liver function
nutritional status
prognosis
