摘要
目的探讨生长抑素联合奥曲肽治疗对肝硬化上消化道出血患者炎性介质、氧化应激及凝血功能的影响。方法选取2021年1月至2023年2月如皋市人民医院收治的122例肝硬化上消化道出血患者作为研究对象,根据治疗方案的不同分为对照组60例(采用奥曲肽治疗)和观察组62例(采用生长抑素联合奥曲肽治疗)。分析两组治疗前后炎性介质[白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)、血清C反应蛋白(CRP)]、氧化应激[丙二醛(MDA)、血清胆碱酯酶(CHE)和超氧化物歧化酶(SOD)]、凝血功能[纤维蛋白原(Fibrinogen,FIB)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)以及凝血酶原时间(PT)]以及不良反应发生率。结果治疗后,两组Ⅱ-6、Ⅱ-8、TNF-α及CRP水平均下降,且观察组治疗后Ⅱ-6、Ⅱ-8、TNF-α及CRP水平均低于观察组,差异有统计学意义(P<0.05);两组治疗后CHE、SOD水平升高,且观察组治疗后CHE、SOD水平高于对照组,差异有统计学意义(P<0.05);两组治疗后MDA水平下降,且观察组治疗后MDA水平低于对照组,差异有统计学意义(P<0.05);两组治疗后FIB水平升高,且观察组治疗后FIB水平高于对照组,差异有统计学意义(P<0.05);两组治疗后APTT、TT以及PT水平均下降,且观察组治疗后APTT、TT以及PT水平均低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率对比,差异无统计学意义(P>0.05)。结论应用生长抑素联合奥曲肽治疗肝硬化上消化道出血中可以减轻患者炎性反应,改善凝血障碍,安全性尚可,值得临床推广。
Objective To investigate the effects of somatostatin combined with octreotide therapy on inflammatory mediators,oxidative stress,and blood coagulation in patients with liver cirrhosis combining upper gastrointestinal bleeding.Methods 122 patients with upper gastrointestinal bleeding due to liver cirrhosis admitted to our hospital from January 2021 to February 2023 were selected as the study subjects,and according to different treatment plans,they were divided into 60 cases in the control group(treated with octreotide)and 62 cases in the observation group(treated with somatostatin combined with octreotide therapy).The inflammatory mediators[Interleukin-6(IL-6),Interleukin-8(IL-8),Tumor Necrosis Factor-α(TNF-α)and serum C-reactive protein(CRP)],oxidative stress[malondialdehyde(MDA),serum cholinesterase(CHE)and superoxide dismutase(SOD)],coagulation function[fibrinogen(FIB),activated partial thromboplastin time(APTT),thrombin time(TT)and prothrombin time(PT)]and the incidence of adverse reactions before and after treatment in the two groups were analyzed.Results After treatment,the levels of IL-6,IL-8,TNF-αand CRP in the two groups decreased,and the levels of IL-6,IL-8,TNF-αand CRP in the observation group were lower than those in the control group.The difference was statistically significant(P<0.05).The levels of CHE and SOD in the two groups increased after treatment,and the levels of CHE and SOD in the observation group were higher than those in the control group,the difference was statistically significant(P<0.05).The levels of MDA in the two groups decreased after treatment,and the MDA levels in the observation group were lower than those in the control group after treatment.The difference was statistically significant(P<0.05).FIB levels in the two groups increased after treatment,and FIB levels in the observation group were higher than those in the control group.The difference was statistically significant(P<0.05).APTT,TT and PT levels in the two groups decreased after treatment,and the levels of APTT,TT a
作者
彭静
孙海丽
沈爱
袁宇婷
冯海娟
PENG Jing;SUN Haili;SHEN Ai;YUAN Yuting;FENG Haijuan(Department of Gastroenterology,Rugao People's Hospital,Nantong,Jiangsu,China,226500)
出处
《分子诊断与治疗杂志》
2023年第12期2044-2047,2052,共5页
Journal of Molecular Diagnostics and Therapy
基金
江苏省卫生健康委医学科研项目(M20214023)。
关键词
生长抑素
奥曲肽
肝硬化上消化道出血
炎性介质
氧化应激
凝血功能
Somatostatin
Octreotide
Upper gastrointestinal bleeding in cirrhosis
Inflammatory mediators
Oxidative stress
Coagulation function
