摘要
目的:旨在探讨慢性束缚应激焦虑模型大鼠的不同焦虑程度与自主运动意愿的关系。方法:将24只雄性6 w龄SD大鼠分为空白对照组(C组,n=8)和模型组(M组,n=16),模型组进行4 w慢性束缚应激造模,造模完成后采用高架十字迷宫、蔗糖偏好实验来评价动物模型是否成功建立,并根据行为学测试结果将模型大鼠分为轻度焦虑组(M1组,n=8)和重度焦虑组(M2组,n=8);C组安静饲养4 w。采用自主转轮系统监测24 h内大鼠自主运动量。结果:(1)与C组相比,M组大鼠在高架十字迷宫中的总路程、开臂进入次数及开臂路程均减少,结果具有显著统计学差异。(2)与C组相比,M1组和M2组高架十字迷宫总路程(P<0.01)、开臂进入次数(P<0.01)和开臂路程(P<0.05)均显著下降;与M1组相比,M2组高架十字迷宫总路程(P<0.05)、开臂进入次数(P<0.01)和开臂路程(P<0.01)均显著下降。(3)与C组相比,M1组和M2组蔗糖偏好率(P<0.05)显著下降;与M1组相比,M2组蔗糖偏好率(P<0.05)显著下降。(4)与C组相比,M1组和M2组大鼠自主转轮运动量(P<0.05)显著降低,与M1组相比,M2组自主转轮运动量(P<0.05)显著下降。结论:慢性束缚应激大鼠的焦虑程度与自主运动意愿存在相关性,焦虑程度越严重,自主运动意愿越低。
OBJECTIVE:This study aimed to explore the relationship between different levels of anxiety and voluntary exercise willingness in rats using a chronic restraint stress anxiety model.METHODS:Twenty-four male 6-week-old SD rats were divided into a control group(C group,n=8)and a model group(M group,n=16).The model group was subjected to 4 weeks of chronic restraint stress to establish the anxiety model.The elevated plus maze and sucrose preference test were used to evaluate the successful establishment of the animal model.Based on the behavioral test results,the model rats were further divided into a mild anxiety group(M1 group,n=8)and a severe anxiety group(M2 group,n=8).The C group was kept undisturbed for 4 weeks.The voluntary wheel-running system was used to monitor the rats’voluntary exercise amount within 24 hours.RESULTS:(1)Compared to the C group,the M group rats showed a significant decrease in total distance traveled,number of entries into the open arms,and distance traveled in the open arms in the elevated plus maze.(2)Compared to the C group,both the M1 and M2 groups showed significant decreases in total distance traveled(P<0.01),number of entries into the open arms(P<0.01),and distance traveled in the open arms(P<0.05)in the elevated plus maze.Additionally,the M2 group showed significant decreases in these parameters compared to the M1 group(P<0.05 for total distance,P<0.01 for number of entries,and P<0.01 for distance traveled in the open arms).(3)Compared to the C group,both the M1 and M2 groups showed a significant decrease in sucrose preference rate(P<0.05),and the M2 group showed a significant decrease compared to the M1 group(P<0.05).(4)Compared to the C group,both the M1 and M2 groups showed a significant reduction in voluntary wheel-running activity(P<0.05),and the M2 group showed a significant decrease compared to the M1 group(P<0.05).CONCLUSION:There is a correlation between the level of anxiety and voluntary exercise willingness in rats subjected to chronic restraint stress,with more severe
作者
陈登嵩
郑密
周司晨
邢玉琦
李莹
Chen Dengsong;Zheng Mi;Zhou Sichen;Xing Yuqi;Li Ying(Harbin Sports University,Harbin 150008,China)
出处
《体育科技文献通报》
2024年第6期235-237,共3页
Bulletin of Sport Science & Technology
关键词
慢性束缚应激
焦虑症
自主运动
chronic restraint stress
anxiety disorder
voluntary exercise
