摘要
目的 分析川崎病(KD)急性期中性粒淋巴细胞比值(NLR)、血小板淋巴细胞比值(PLR)的变化及其临床应用价值。方法 选取2017年1月1日至2023年8月8日于内蒙古科技大学包头医学院第一附属医院住院治疗诊断为KD的患儿85例为KD组,并选取同期收治的存在发热(腋温≥37.5℃且时间≥5 d)的呼吸道感染患儿82例为对照组。比较两组患儿的实验室检测指标,包括白细胞(WBC)、红细胞(RBC)、血红蛋白(HGB)、中性粒细胞(NEUT)、淋巴细胞(LYMPH)、单核细胞(MONO)、血小板(PLT)、平均血小板体积(MPV)、NLR、 PLR、平均血小板体积与淋巴细胞比值(MPVLR)、 C-反应蛋白(CRP)及病原学检测结果。采用二元Logistic回归分析KD患病的独立危险因素,以ROC曲线评估NLR、PLR的诊断效能。结果 (1)KD组患儿的WBC、 NEUT、 PLT、 NLR、 PLR、 CRP高于对照组,而LYMPH、 MPV低于对照组,差异均有统计学意义(P<0.05);(2)两组患儿的RBC、 HGB、 MONO、 MPVLR、细菌感染、病毒感染、支原体感染情况比较,差异无统计学意义(P>0.05);(3)二元Logistic回归分析结果显示,NLR和PLR是发生KD的独立危险因素(P<0.05);(4)ROC曲线分析结果显示,NLR、 PLR和两者联合预测发生KD的灵敏度分别为63.90%、 65.10%、 62.70%,特异度分别为86.30%、 77.50%、 86.30%, AUC分别为0.788、 0.765、 0.824(P<0.05)。结论KD的发生与病原体感染有关;NLR、PLR比值越高,KD的患病风险越大,NLR联合PLR检测对诊断KD有一定的临床价值。
Objective To analyze the changes of neutrophil lymphocyte ratio(NLR)and platelet lymphocyte ratio(PLR)in the acute phase of Kawasaki disease(KD)and their clinical value.Methods We selected children diagnosed with KD as KD group(85 cases),from the First Affiliated Hospital of Baotou Medical College,January 1,2017 to August 8,2023,and children with respiratory tract infection characterized by fever(axillary temperature≥37.5℃for≥5 days)as control group(82 cases).The laboratory test indicators of the two groups were compared,including white blood cells(WBC),red blood cells(RBC),hemoglobin(HGB),neutrophils(NEUT),lymphocytes(LYMPH),monocytes(MONO),platelets(PLT),mean platelet volume(MPV),NLR,PLR,mean platelet volume to lymphocyte ratio(MPVLR),C-reactive protein(CRP)and microbiology test results.The independent risk factors of KD were analyzed by binary logistic regression,and the diagnostic efficacy of NLR and PLR was evaluated by ROC curve.Results(1)WBC,NEUT,PLT,NLR,PLR and CRP in KD group were higher than those in control group(P<0.05),while LYMPH and MPV were lower than those in control group(P<0.05).(2)There were no significant differences in RBC,HGB,MONO,MPVLR,bacterial infection,viral infection and mycoplasma infection between the two groups(P>0.05).(3)Binary logistic regression analysis revealed that NLR and PLR were independent risk factors for KD(P<0.05).(4)ROC curve analysis showed that the sensitivity of NLR,PLR and their combination in predicting the occurrence of KD was 63.90%,65.10%and 62.70%,respectively,while the specificity were 86.30%,77.50%and 86.30%,respectively.AUC values were 0.788,0.765 and 0.824,respectively(P<0.05).Conclusion The occurrence of KD is associated with pathogenic infections.The higher the NLR to PLR ratio,the greater the risk of KD.The combination of NLR and PLR detection has certain clinical value in diagnosing KD.
作者
郭苗
刘启
张宏
郝玉青
温红艳
GUO Miao;LIU Qi;ZHANG Hong;HAO Yuqing;WEN Hongyan(Department of Pediatrics,the First Affiliated Hospital of Baotou Medical College,Inner Mongolia University of Science and Technology,Baotou 014010,China;Department of Radiology,the Second Affiliated Hospital of Baotou Medical College,Inner Mongolia University of Science and Technology,Baotou 014030,China)
出处
《大连医科大学学报》
CAS
2024年第2期144-148,共5页
Journal of Dalian Medical University
