摘要
目的探讨结直肠癌与脂质代谢异常以及TyG、TG/HDL-C等因素的相关性分析,为结直肠癌的筛查及预防提供参考指标。方法收集2022年1—12月于包头医学院第二附属医院住院治疗的患者,从医疗记录中收集数据。共收集589例患者数据,其中包括病史、体格检查和实验室检查,分为癌症组及非癌症组,对研究对象的性别、年龄、BMI、肥胖、吸烟、饮酒、高血压、糖尿病、甘油三酯、总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、空腹血糖、肌酐、尿酸、谷丙转氨酶、天门冬氨酸氨基转移酶、总蛋白、白蛋白、TyG、TG/HDL-C进行χ^(2)、秩和检验,采取单因素和多因素Logistic回归分析结直肠癌的危险因素。结果两组肥胖、吸烟、饮酒、高血压、糖尿病比较差异有统计学意义(P<0.05)。两组年龄、BMI、甘油三酯、总胆固醇、空腹血糖、TyG、TG/HDL-C比较差异有统计学意义(P<0.05)。对TyG、TG/HDL-C和TyG+TG/HDL-C是否能预测癌症进行ROC曲线分析,TyG、TG/HDL-C和TyG+TG/HDL-C均能预测癌症。结论肥胖及TyG、TG/HDL-C与结直肠癌存在相关性,对结直肠癌具有一定的预测性。
Objective To investigate the correlation analysis of colorectal cancer with abnormal lipid metabolism and factors such as TyG and TG/HDL-C,and to provide reference indexes for colorectal cancer screening and prevention.Method This study is a retrospective study from patients hospitalized in our hospital between January and December 2022 and collected data from medical records.A total of 589 patients had data were collected,including patient history,physical examination and laboratory tests.Is divided into cancer group and non-cancer group,the gender,obesity,smoking,alcohol consumption,hypertension,diabetes,age,BMI,triglyceride,total cholesterol,high density lipoprotein cholesterol,low density lipoprotein cholesterol,fasting blood glucose,creatinine,uric acid,alanine aminotransferase,aspartate amino transferase,total protein,TyG,TG/HDL-C,regression analysis using univariate and multivariate Logistic regression analysis of the risk factors of colorectal cancer.Results There were significant differences in obesity,smoking,alcohol,hypertension and diabetes(P<0.05).There were significant differences in age,BMI,triglycerides,total cholesterol,fasting blood glucose,TyG and TG/HDL-C(P<0.05).ROC curves for TyG,TG/HDL-C and TyG+TG/HDL-C on the presence or absence of cancer,TyG,TG/HDL-C and TyG+TG/HDL-C predicted cancer(P<0.05).Conclusion Obesity and metabolic indicators TyG and TG/HDL-C were associated with colorectal cancer,which is somewhat predictive for colorectal cancer.
作者
蔡彤辉
刘迎春
王驰
CAI Tonghui;LIU Yingchun;WANG Chi(The Second Affiliated Hospital of Baotou Medical College,Inner Mongolia University of Science and Technology,Baotou 014030 China)
出处
《内蒙古医学杂志》
2024年第4期412-418,共7页
Inner Mongolia Medical Journal
