摘要
心房颤动(简称“房颤”)是临床上最常见的心律失常,炎症反应在房颤的发生和发展中起着重要作用。炎症性肠病(IBD)是一种慢性非特异性炎症性疾病,包括克罗恩病和溃疡性结肠炎。近年来研究发现,IBD与动脉粥样硬化性心血管疾病的风险增加有关,但其与房颤的关系尚未完全明确。最近的流行病学证据表明IBD和房颤之间存在关联,特别是在发作或住院期间。本文就IBD和房颤关系、共同的致病机制以及IBD药物对房颤的影响进行综述。
Atrial fibrillation(AF) is the most common arrhythmia in clinical practice, and the inflammatory response plays an important role in the development and progression of AF. Inflammatory bowel disease(IBD) which includes Crohn disease(CD) and ulcerative colitis(UC), is a chronic nonspecific inflammatory disease. Recent studies have found that IBD is associated with an increased risk of atherosclerotic cardiovascular disease, but its relationship with AF has not been fully clarified. Recent epidemiological evidence suggests an association between IBD and AF, especially during flares or hospitalizations. This article reviews the relationship between IBD and AF, common pathogenic mechanisms, and the impact of IBD medications on AF.
作者
张琪
刘改珍
ZHANG Qi;LIU Gaizhen(Department of Cardiovascular Medicine,The Second Clinical Medical College of Shanxi Medical University,Second Hospital of Shanxi Medical University,Taiyuan030001,Shanxin,China)
出处
《中国分子心脏病学杂志》
CAS
2024年第1期5943-5948,共6页
Molecular Cardiology of China
基金
山西省应用基础研究计划(201901D211497)。
关键词
心房颤动
炎症性肠病
炎症
免疫失衡
Atrial fibrillation
Inflammatory bowel disease
I Inflammation
Immune imbalance
