摘要
饮食的炎症效应与恶性肿瘤的发生发展密切相关,因此饮食相关炎症指数作为探究饮食、炎症和肿瘤关系的方法学工具应运而生。本文复习了肿瘤流行病学相关研究文献,针对饮食相关炎症指数与消化系统常见肿瘤的流行病学研究进展进行归纳和总结。现有流行病学证据提示:促炎饮食与消化系统恶性肿瘤发病风险增加有关,其中与结直肠癌关联最强,其次是食管癌和胃癌,然后是胰腺癌,与肝癌的研究证据最少;食管癌的研究证据级别较低,胃癌的研究存在性别差异和混杂因素调整的问题,胰腺癌的研究结果存在异质性;针对目前研究进展和不足,未来可考虑开展前瞻性研究或人群队列研究,以及加强对肝癌等常见肿瘤的相关营养流行病学研究。本文可为消化系统肿瘤预防和控制中促进相关健康饮食行为的宣教工作提供参考。
The inflammatory effect of dietary is strongly related to the development of cancer,therefore,the diet-related inflammatory index was developed as a methodological tool to investigate the relationship between dietary,inflammation and tumors.In this paper,we summarized the results on diet-related inflammatory indices and common cancers of the digestive system based on relevant cancer epidemiological studies.The available epidemiological evidence suggests that pro-inflammatory diet is associated with an increased risk of gastrointestinal malignancies,with the strongest association with colorectal cancer,followed by esophageal and gastric cancers,and then pancreatic cancer,and the least evidence of studies with liver cancer.Among these studies,the level of evidence for esophageal cancer is lower than colorectal cancer,the study of gastric cancer has gender differences and problems in adjusting for confounders,and the study of pancreatic cancer has heterogeneous results.In view of the current research progress and deficiencies,prospective studies or population-based cohort studies,as well as strengthening nutritional epidemiological studies related to common tumors such as liver cancer could be considered in the future.This review is expecting to provide basic information and scientific basis for strengthening the related healthy eating behavior promotion in the prevention and control of digestive system tumors.
作者
谭靖宇
张妍
陈俊
杨丹妮
邹一鑫
杨万水
项永兵
TAN Jing-yu;ZHANG Yan;CHEN Jun;YANG Dan-ni;ZOU Yi-xin;YANG Wan-shui;XIANG Yong-bing(School of Public Health,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China;School of Public Health,Fudan University,Shanghai 200032,China;Department of Epidemiology,Shanghai Cancer Institute,Shanghai 200032,China;School of Public Health,Anhui Medical University,Hefei 230032,Anhui Province,China;State Key Laboratory of Systems Medicine for Cancer,Renji Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200032,China)
出处
《复旦学报（医学版）》
CAS
CSCD
北大核心
2024年第3期404-414,共11页
Fudan University Journal of Medical Sciences
基金
国家重点研发计划(2021YFC2500404,2021YFC2500405)。
关键词
饮食相关炎症指数
消化系统肿瘤
炎症
前瞻性研究
流行病学
diet-related inflammatory indices
digestive system cancer
inflammation
prospective cohort study
epidemiology
