摘要
目的 分析血清降钙素原(PCT)和序贯器官衰竭评分(SOFA)评分对脓毒症患者预后的联合预测价值。方法 收集南阳市第一人民医院2020年1月~2021年12月收治的162例脓毒症患者,均随访3个月,依据结局分为死亡组(79例)和存活组(83例),采用Logistic多因素回归分析脓毒症患者死亡的危险因素,ROC曲线分析PCT联合SOFA评分对脓毒症患者预后的预测价值。结果 与存活组相比,死亡组患者年龄≥60岁占比升高,体温、心率、急性生理与慢性健康(APACHEⅡ)评分、C反应蛋白(CRP)水平、SOFA评分、血清白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、白细胞介素-10(IL-10)、肿瘤坏死因子-α(TNF-α)、PCT均升高(P<0.05)。进一步行Logistic多因素回归分析PCT、SOFA评分升高为脓毒症患者死亡的危险因素(P<0.05)。PCT、SOFA评分对脓毒症患者预后均有一定预测价值,PCT+SOFA评分二者联合预测价值优于各指标单独预测(P<0.05)。结论 PCT、SOFA评分升高为脓毒症患者死亡的危险因素,且二者联合评估脓毒症患者预后预测价值更高。
Objective To analyze the combined predictive value of serum procalcitonin(PCT)and sequential organ failure score(SOFA)scores for the prognosis of sepsis patients.Methods A total of 162 patients with sepsis admitted to the First People's Hospital of Nanyang City from January 2020 to December 2021 were collected and followed up for 3 months.They were divided into a death group(79 cases)and a survival group(83 cases)based on the outcome.Logistic multiple regression analysis was used to identify the risk factors for sepsis patient mortality,and ROC curve analysis was used to evaluate the predictive value of PCT combined with SOFA score for the prognosis of sepsis patients.Results Compared with the survival group,the proportion of patients aged≥60 years in the death group increased.Body temperature,heart rate,acute physiological and chronic health(APACHE II)score,C-reactive protein(CRP)level,SOFA score,serum interleukin-6(IL-6),interleukin-8(IL-8),interleukin-10(IL-10),tumor necrosis factor-α(TNF-α),and PCT were all elevated in the death group(P<0.05).Further logistic multiple regression analysis showed that elevated PCT and SOFA scores were risk factors for mortality in sepsis patients(P<0.05).PCT and SOFA scores had certain predictive value for the prognosis of sepsis patients,and the combined predictive value of PCT+SOFA score was better than that of each indicator alone(P<0.05).Conclusion Elevated PCT and SOFA scores are risk factors for mortality in sepsis patients,and the combined evaluation of the two has higher predictive value for the prognosis of sepsis patients.
作者
赵鑫
孟泉辛
Zhao Xin;Meng Quanxin(Nanyang First People's Hospital,Nanyang 473000,China)
出处
《华北理工大学学报（医学版）》
2024年第3期228-232,共5页
Journal of North China University of Science and Technology：Health Sciences Edition
关键词
脓毒症
血清降钙素原
序贯器官衰竭评分
预后
预测
Sepsis
Serum procalcitonin
Sequential organ failure assessment
Prognosis
Prediction
