摘要
目的探讨加巴喷丁联合甲钴胺对脑梗死继发不宁腿综合征的治疗效果。方法纳入2022年1月—2023年12月在南阳市第一人民医院接受治疗的脑梗死继发不宁腿综合征患者62例,根据治疗方式分为对照组(n=30,甲钴胺)和观察组(n=32,加巴喷丁联合甲钴胺)。治疗前和治疗后评估两者患者不宁腿症状、焦虑情绪、抑郁情绪、睡眠质量,分析血红蛋白水平与不宁腿症状相关性。结果治疗前,两组患者不宁腿症状评分、汉密尔顿焦虑量表(HAMA)评分、汉密尔顿抑郁量表(HAMD)评分和匹兹堡睡眠质量指数(PSQI)评分均相近,差异无统计学意义(均P>0.05);治疗后,观察组和对照组不宁腿症状评分[分别为(8.35±2.91)分vs(18.83±3.74)分]、HAMA评分[分别为(8.91±2.10)分vs(16.23±2.78)分]、HAMD评分[分别为(7.47±2.92)分vs(17.76±2.34)分]和PSQI评分[分别为(6.35±1.36)分vs(13.83±1.64)分]比较,差异均有统计学意义(均P<0.05)。53例(85%)患者血红蛋白水平正常,9例(15%)患者血红蛋白水平偏低。结论加巴喷丁联合甲钴胺对脑梗死继发不宁腿综合征可能具有更好的治疗效果,值得在临床中进一步大样本研究。
Objective To investigate the therapeutic effect of gabapentin combined with mecobalamin on restless leg syndrome secondary to cerebral infarction.Methods A total of 62 patients with cerebral infarction complicated with restless leg syndrome treated in our hospital from January 2022 to December 2023 were included in this study.They were divided into a control group(n=30,treated with mecobalamin)and an observation group(n=32,treated with gabapentin combined with mecobalamin)based on their treatment modalities.Restless leg symptoms,anxiety,depression,sleep quality and hemoglobin levels were determined before and after treatment in both groups.Hemoglobin levels were analyzed for their association with restless leg symptoms.Results Before treatment,the symptoms of restless legs,Hamilton Anxiety Inventory(HAMA),Hamilton Depression Rating Scale(HAMD)and Pittsburgh Sleep Quality Index(PSQI)scores were similar between the two groups,and the difference was not statistically significant(all P>0.05).After treatment,the observation group and the control group had restless leg symptom scores[(8.35±2.91)vs(18.83±3.74)],HAMA score[(8.91±2.10)vs(16.23±2.78)],HAMD score[(7.47±2.92)vs(17.76±2.34)],and PSQI[(6.35±1.36)vs(13.83±1.64),respectively]and the differences were statistically significant(all P<0.05).Hemoglobin levels in 53 patients(85%)were normal.Hemoglobin levels were lower than normal in 9 patients(15%).Conclusion Gabapentin combined with mecobalamin can have a significant therapeutic effect on restless leg syndromes secondary to cerebral infarction and is worthy of further study of large sample in clinical practice.
作者
赵婷
王芳芳
马田清
焦淑洁
Zhao Ting;Wang Fang-fang;Ma Tian-qing;Jiao Shu-jie(Department of Neurology,the First Affiliated Hospital,Zhengzhou University,Zhengzhou 450052,China;Department of Neurology,Nanyang First People's Hospital,Nanyang 473000,China)
出处
《中国药物应用与监测》
CAS
2024年第2期144-147,共4页
Chinese Journal of Drug Application and Monitoring
关键词
脑梗死
加巴喷丁
甲钴胺
不宁腿综合征
Cerebral infarction
Gabapentin
Methylcobalamin
Restless leg syndrome
