摘要
目的探讨CT灌注成像在孤立性肺结节良恶性鉴定诊断中的应用价值。方法回顾性分析2022年1月—2023年3月在南安市医院就诊的68例孤立性肺结节患者的临床资料,根据经皮肺穿刺病理活检、纤支镜活检、手术病理等检查结果将患者分为良性结节组(n=43)与恶性结节组(n=25),在病理活检前接受CT灌注成像检查,比较2组CT灌注成像相关参数。结果2组的平均通过时间(mean transit time,MTT)比较,差异无统计学意义(P>0.05)。恶性结节组的血流量(blood flow,BF)、血容量(blood volume,BV)、毛细血管表面通透性(capillary permeability surface area product,PS)值明显高于良性结节组(P<0.05)。经受试者工作特征(receiver operating characteristic,ROC)曲线分析显示,当BF阈值为72.175 mL/(100 g·min),BV阈值为4.815 mL/100 g,PS阈值为8.190 mL/(100 g·min)时,鉴定诊断结节良恶性的曲线下面积分别为0.910、0.935、0.956,敏感度分别为84.00%、96.00%、92.00%。结论CT灌注成像能够直观显示孤立性肺结节的全貌,其中CT灌注成像参数BV值、BF值、PS值对鉴别诊断结节良恶性有较高的临床价值。
Objective To explore the application value of CT perfusion imaging in the identification and diagnosis of benign and malignant solitary pulmonary nodules.Methods The clinical data of 68 patients with solitary pulmonary nodules treated in Nan'an Hospital from January 2022 to March 2023 were retrospectively analyzed.The patients were divided into benign nodule group(n=43)and malignant nodule group(n=25)according to the results of percutaneous pulmonary puncture pathological biopsy,fiberoptic biopsy and surgical pathology.CT perfusion imaging was performed before pathological biopsy.The relevant parameters of CT perfusion imaging were compared between the two groups.Results There were no significant difference in mean transit time(MTT)values between the two groups(P>0.05).The blood flow(BF),blood volume(BV),capillary permeability surface area product(PS)values in the malignant nodule group were significantly higher than those in the benign nodule group(P<0.05).According to receiver operating characteristic(ROC)curve analysis,when the BF threshold was 72.175 mL/(100 g·min),BV threshold was 4.815 mL/100 g,and PS threshold was 8.190 mL/(100 g·min),the area under the curve for identifying benign and malignant nodules were 0.910,0.935,0.956,and the sensitivity were 84.00%,96.00%,and 92.00%,respectively.Conclusion CT perfusion imaging can visually display the full view of solitary pulmonary nodules,and the parameters BV,BF and PS values of CT perfusion imaging have high clinical value in distinguishing between benign and malignant nodules.
作者
吴小凯
肖开
杨君玲
WU Xiaokai;XIAO Kai;YANG Junling(Department of Imaging,Nan'an Hospital,Nan'an Fujian 362300,China;Department of Interventional,the First Affiliated Hospital of Fujian Medical University,Fuzhou Fujian 350005,China)
出处
《中国卫生标准管理》
2024年第9期128-131,共4页
China Health Standard Management
关键词
孤立性肺结节
CT灌注成像
鉴别诊断
良恶性
血容量
表面渗透系数
solitary pulmonary nodules
CT perfusion
differential diagnosis
benign or malignant
blood volume
permeability surface
