摘要
目的探讨2型糖尿病(T2DM)合并冠心病患者外周血辅助性T细胞(Th)17比例及其相关细胞因子的变化及临床意义。方法选取2021年2月至2022年6月于天津医科大学朱宪彝纪念医院心内科就诊并完成冠状动脉造影(CAG)检查的T2DM患者138例, 根据CAG结果分为T2DM合并冠心病组(72例), 单纯T2DM组(66例), 选取同期健康体检者42名作为对照组。收集患者临床资料及生化指标, 检测外周血Th17细胞比例及白细胞介素(IL)-17、IL-6、IL-23的表达水平。应用SPSS 22.0软件进行单因素方差分析、t检验、秩和检验、χ2检验、偏相关分析及logistic回归分析。结果 T2DM合并冠心病组Th17细胞比例及IL-17、IL-6、IL-23水平显著高于T2DM组及对照组(P均<0.05)。T2DM合并冠心病组Th17细胞比例与IL-17(r=0.827)及IL-6(r=0.824)水平呈正相关(P均<0.05)。Logistic回归分析显示Th17细胞比例、IL-17、IL-6水平及空腹血糖(FPG)是T2DM合并冠心病的独立危险因素(P均<0.05)。结论与T2DM患者相比, T2DM合并冠心病患者体内可能存在更为严重的炎性反应, Th17细胞比例、IL-17及IL-6水平可能是T2DM合并冠心病的危险因素。
Objective To investigate the changes and clinical significance of peripheral blood helper T cell(Th)17 ratio and its related cytokine expression levels in patients with type 2 diabetes mellitus(T2DM)combined with coronary heart disease.Methods 138 patients with T2DM who attended the Department of Cardiology of Department of Cardiology,Tianjin Medical University Chu Hsien-I Memorial Hospital and completed coronary angiography(CAG)from February 2021 to June 2022 were selected,including 72 patients in the group of T2DM combined with coronary heart disease,66 patients in the group of T2DM alone,and 42 patients who had a healthy physical examination during the same period were selected as the control group.The clinical data and biochemical indexes of the patients were collected,and the peripheral blood Th17 cell ratio and the expression levels of interleukin(IL)-17,IL-6,and IL-23 were detected.SPSS 22.0 software was applied to perform one-way ANOVA,t-test,rank sum test,χ2 test,partial correlation analysis,and logistic regression analysis.Results The proportion of Th17 cells,and the levels of IL-17,IL-6,and IL-23 in the T2DM combined coronary heart disease group were significantly higher than those in the T2DM group and the control group(all P<0.05).The proportion of Th17 cells in the T2DM combined coronary heart disease group was positively correlated with the levels of IL-17(r=0.827)and IL-6(r=0.824)(All P<0.05).Logistic regression analysis showed that the proportion of Th17 cells,IL-17,IL-6 levels,and fasting glucose(FPG)were independent risk factors for coronary heart disease complicating T2DM(all P<0.05).Conclusion Compared with T2DM patients,patients with T2DM combined with coronary heart disease may have more severe inflammation,and the proportion of Th17 cells,IL-17,and IL-6 levels may be risk factors for T2DM combined with coronary heart disease.
作者
宋云萍
杨琴
于翔
Song Yunping;Yang Qin;Yu Xiang(Department of Cardiology Tianjin Medical University Chu Hsien-I Memorial Hospital NHC Key Laboratory of Hormones and Development Tianjin Key Laboratory of Metabolic Diseases,Tianjin 300134,China)
出处
《国际内分泌代谢杂志》
2024年第2期83-87,共5页
International Journal of Endocrinology and Metabolism
基金
天津市医学重点学科(专科)建设项目(TJYXZDXK-032A)
天津医科大学朱宪彝纪念医院科研基金(ZXYZDSYS20208)。
关键词
2型糖尿病
冠心病
辅助性T细胞17
白细胞介素
Type 2 diabetes mellitus
Coronary heart disease
Helper T cell 17
Interleukin
