摘要
早发性卵巢功能不全(premature ovarian insufficiency,POI)是指在女性40岁之前卵巢功能衰退或丧失,导致女性不孕的常见原因,其发病机制复杂。近期微生物群与生殖内分泌疾病的研究成为了热点,本综述菌群通过免疫反应、炎症因子及代谢功能等途径参与POI的发生发展过程,同时通过服用益生菌、粪便微生物群移植等方式能够改善菌群失调,从而改善POI相关症状。未来有望通过菌群与POI机制的进一步研究,为POI的诊治提供新的策略。
Premature ovarian insufficiency(POI)is characterized by the decline or loss of ovarian function before the age of 40 years and account for one major cause of female infertility.Its pathogenesis is complex.Recently,the research on microbiota and reproductive endocrine diseases has become a hot spot.This article reviews the involvement of microbiota in the occurrence and development of POI through immune response,inflammatory factors and metabolic function.At the same time,taking probiotics and fecal microbiota transplantation can correct the dysbiosis of flora,so as to improve the symptoms associated with POI.In the future,it is expected to provide new strategies for the diagnosis and treatment of POI through further research on the relationship between microbiota and POI.
作者
宋艳琴
吴亚妹
周知
马宁
万邦贝
卢伟英
Song Yanqin;Wu Yamei;Zhou Zhi;Ma Ning;Wan Bangbei;Lu Weiying(Reproductive Medical Center,Hainan Women and Children's Medical Center,Haikou 570206,China)
出处
《中华生殖与避孕杂志》
CAS
CSCD
北大核心
2024年第3期310-314,共5页
Chinese Journal of Reproduction and Contraception
基金
国家自然科学基金(82260304)。
关键词
早发性卵巢功能不全
肠道菌群
阴道微生态
发病机制
治疗
Premature ovarian insufficiency
Gut microbiome
Vaginal microbiota
Pathogenic mechanism
Therapy
