摘要
The ovary is a vital female reproductive organ that functions to produce oocyte gametes and cyclically expressed sex hormones to maintain reproductive capacity and hormone homeostasis.Ovarian aging,characterized by declines in follicle quantity and oocyte quality,leads to premature ovarian failure,premature ovarian insufficiency,or diminished ovarian reserve,thus contributing to female infertility.Distinct gene-expression signatures from RNA transcriptional level and post-transcriptional regulation are relative to oocyte quality and reproductive age.
基金
funded by the National Natural Science Foundation of China,China(92168104,82071720)
the National Key Project of Research and Development Program(2021YFC2700602)
Jiangsu Province 333 Talent Grant(2022-3-2-155)
Suzhou Talent Training Program(GSWS2019005,GSWS2020057)
Jiangsu Provincial Medical Key Discipline(Laboratory)Cultivation Unit(JSDW202214)
Medical research project of Jiangsu Commission of Health(M2020060)
Suzhou Youth Project of Science and Education for Medicine(KJXW2022036).
