摘要
Collagen,the main component of mammal skin,has been traditionally used in leather manufacturing for thousands of years due to its diverse physicochemical properties.Collagen is the most abundant protein in mammals and the main component of the extracellular matrix(ECM).The properties of collagen also make it an ideal building block for the engineering of materials for a range of biomedical applications.Reproductive medicine,especially human fertility preservation strategies and reproductive organ regeneration,has attracted significant attention in recent years as it is key in resolving the growing social concern over aging populations worldwide.Collagen-based biomaterials such as collagen hydrogels,decellularized ECM(dECM),and bioengineering techniques including collagen-based 3D bio-printing have facilitated the engineering of reproductive tissues.This review summarizes the recent progress in apply-ing collagen-based biomaterials in reproductive.Furthermore,we discuss the prospects of collagen-based materials for engineering artificial reproductive tissues,hormone replacement therapy,and reproductive organ reconstruction,aiming to inspire new thoughts and advancements in engineered reproductive tissues research.
基金
the Sichuan Science and Technology Program(L.Q.,Grant No.2020YFS0127)
the Y.Z.laboratory was financially supported by the Research project of Science&Technology Department of Sichuan Province(Y.Z.,Grant No.2021YJ0416)
project of Chengdu Science and Technology Bureau,(Y.Z.,Grant No.2021-YF05-02110-SN)National Natural Science Foundation of China(Y.Z.,Grant No.82001496)
China Postdoctoral Science Foundation(Y.Z.,Grant No.2020M680149,2020T130087ZX)
the National Global Talents Recruitment Program(J.G.),National Natural Science Foundation of China(22178233)
Talents Program of Sichuan Province,Double First Class University Plan of Sichuan University,State Key Laboratory of Polymer Materials Engineering(J.G.,Grant No.sklpme 2020-3-01).
