摘要
早发性卵巢功能不全(premature ovarian insufficiency,POI)是女性在40岁之前出现卵巢功能减退的临床综合征,表现为生殖和内分泌功能的减弱,是导致女性不孕的重要因素之一,但其发病机制不明、治疗手段有限。褪黑素主要是由松果体合成和分泌的神经内分泌激素,具有调节昼夜节律、抗氧化、清除自由基等作用。研究表明,褪黑素参与调节卵巢类固醇激素合成、卵泡发育、排卵和卵母细胞质量。POI动物模型研究发现褪黑素可减轻氧化应激,减少细胞凋亡,通过调节多条信号通路发挥调节卵巢功能和延缓POI的作用。临床研究表明褪黑素可改善POI患者的卵巢功能,提高妊娠率。其在辅助生殖中有潜在的应用价值,为提高POI患者的生育力提供了新的方向。
Premature ovarian insufficiency(POI)is a clinical syndrome in women who develops ovarian insufficiency before the age of 40 years,which manifests itself as a weakening of reproductive and endocrine functions,and is one of the most important factors leading to female infertility,but the pathogenesis is unknown and the treatment is limited.Melatonin is a neuroendocrine hormone mainly synthesized and secreted by the pineal gland,which exerts effects in regulating circadian rhythms,antioxidant activity,and scavenging free radicals.Studies have shown that melatonin is involved in regulating ovarian steroid hormone synthesis,follicular development,ovulation and oocyte quality.Animal models for studies of POI have found that melatonin can alleviate oxidative stress,reduce apoptosis,regulate ovarian function and delay POI through the regulation of multiple signaling pathways.Clinical studies have shown that melatonin can improve ovarian function and pregnancy rate in POI patients.Its potential value in assisted reproduction provides a new direction to improve the fertility of POI patients.
作者
寿梦娜
黄艺舟
周坚红(审校)
SHOU Meng-na;HUANG Yi-zhou;ZHOU Jian-hong(Department of Gynecology,Women′s Hospital,School of Medicine,Zhejiang University,Hangzhou 310006,China)
出处
《国际妇产科学杂志》
CAS
2024年第2期133-136,共4页
Journal of International Obstetrics and Gynecology
基金
浙江省自然科学基金(LY22H040004)
浙江大学医学院附属妇产科医院“4+X”临床研究项目(ZDFY2022-4XA101)。
