摘要
目的探究茵陈蒿汤联合还原型谷胱甘肽对慢性乙型肝炎(CHB)患者的临床疗效。方法选取2020年5月—2022年5月宜丰县人民医院收治的CHB患者60例,依据不同治疗方式分为两组,观察组采用茵陈蒿汤联合还原型谷胱甘肽治疗,对照组采用还原型谷胱甘肽治疗。比较两组肝功能、生活质量评分、临床疗效、不良反应发生率、肝纤维化指标水平等。结果治疗后,两组总胆红素(TBil)比较,差异无统计学意义(P>0.05);观察组天门冬氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)低于对照组(P<0.05);观察组社会、环境、躯体、心理评分高于对照组(P<0.05);观察组的Ⅳ型胶原(Ⅳ-C)、层黏连蛋白(LN)、Ⅲ型前胶原(PCⅢ)、透明质酸(HA)指标均明显低于对照组,差异有统计学意义(P<0.05)。观察组治疗总有效率96.67%(29/30)高于对照组的66.67%(20/30)(P<0.05);观察组不良反应低于对照组(P<0.05)。结论茵陈蒿汤联合还原型谷胱甘肽治疗CHB患者,对提升临床疗效、改善肝纤维化指标水平、提升生活质量的意义重大,同时能够改善肝功能指标,降低不良反应。
Objective To explore and analyze the curative effect of Yinchenhao decoction combined with reduced glutathione on pa⁃tients with chronic hepatitis B(CHB).Methods From May 2020 to May 2022,60 patients with CHB in Yifeng County People’s Hospi⁃tal were divided into observation group(Yinchenhao decoction combined with reduced glutathione treatment)and control group(re⁃duced glutathione treatment).Liver function,quality of life scores,disease efficacy,adverse reactions,liver fibrosis indicators were compared.Results After treatment,there was no significant difference in total bilirubin(TBil)between the two groups(P>0.05).Aspar⁃tate aminotransferase(AST)and alanine aminotransferase(ALT)in observation group were lower than those in control group(P<0.05).Social,environmental,physical and psychological scores of the observation group were higher than those of the control group(P<0.05).The indexes of type IV collagen(Ⅳ-C),laminin(LN),typeⅢprocollagen(PCⅢ)and hyaluronic acid(HA)in observation group were significantly lower than those in control group,with statistical significance(P<0.05).The total effective rate of the observation group was 96.67%(29/30),which was higher than that of the control group(66.67%,20/30)(P<0.05).The adverse reaction of observation group was lower than that of control group(P<0.05).Conclusion Yinchenhao decoction combined with reduced glutathione in the treatment of CHB patients has great significance in improving clinical efficacy,liver fibrosis index level,and quality of life,and can improve liver function index and reduce adverse reactions.
作者
王伟
王沣睿
WANG Wei;WANG Fengrui(Infection Department,Yifeng County People’s Hospital,Jiangxi Province,Yichun 336300,China;Department of Neurology·ICU,Yifeng County People’s Hospital,Jiangxi Province,Yichun 336300,China)
出处
《中国中医药现代远程教育》
2024年第11期150-152,159,共4页
Chinese Medicine Modern Distance Education of China
关键词
慢性乙型肝炎
茵陈蒿汤
还原型谷胱甘肽
中西医结合疗法
chronic hepatitis B
Yinchenhao decoction
reduced glutathione
therapy of integrated traditional Chinese and Western medicine
