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肺结核患者的血清PCT、IFN-γ水平及其与预后的关系

Serum PCT and IFN-r Levels in Patients with Pulmonary Tuberculosis and Their Relationship with Prognosis
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摘要 目的探讨肺结核患者的血清降钙素原(PCT)、干扰素-γ(IFN-γ)水平及其与预后的关系。方法300例肺结核患者根据预后分为预后良好组和预后不良组,比较两组的临床资料,探讨预后的独立影响因素,分析血清PCT、IFN-γ诊断肺结核预后不良的价值。结果肺部感染、肺心病、器官损害、PCT、IFN-γ为肺结核患者预后不良的独立影响因素(P<0.05)。PCT、IFN-γ联合检测诊断肺结核预后不良的AUC高于PCT、IFN-γ单独检测(P<0.05)。结论血清PCT、IFN-γ是肺结核患者预后不良的独立影响因素,检测二者水平有助于早期评估患者的预后情况。 Objective To explore the serum procalcitonin(PCT)and interferon-(IFN-γ)levels in patients with pulmonary tuberculosis and their relationship with prognosis.Methods According to the prognosis,300 patients with pulmonary tuberculosis were divided into good prognosis group and poor prognosis group.The clinical data of the two groups were compared,the independent influencing factors of prognosis were discussed,and the value of serum PCT and IFN-γin the diagnosis of poor prognosis of pulmonary tuberculosis was analyzed.Results Pulmonary infection,pulmonary heart disease,organ damage,PCT and IFN-γwere independent influencing factors of poor prognosis in patients with pulmonary tuberculosis(P<0.05).The AUC of combined detection of PCT and IFNin the diagnosis of poor prognosis of pulmonary tuberculosis was higher than that of single detection of PCT and IFN-γ(P<0.05).Conclusions Serum PCT and IFN-γare independent influencing factors of poor prognosis in patients with pulmonary tuberculosis.Detection of the levels of PCT and IFN-γis helpful for early evaluation of patients'prognosis.
作者 寇军 郭雯 马怡娇 KOU Jun;GUO Wen;MA Yjiao(Clinical Laboratory,Xuchang Infectious Disease Hospital/Xuchang Tuberculosis Prevention and Control Institute,X uchang 461000,China)
出处 《临床医学工程》 2024年第4期511-512,共2页 Clinical Medicine & Engineering
关键词 肺结核 降钙素原 干扰素-Γ 预后 Pulmonary tuberculosis Procalcitonin Interferon-γ Prognosis
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