摘要
目的:探讨对结核感染T细胞γ干扰素释放试验(TB-IGRA)及结核杆菌抗体(TB-Ab)在肺结核患者诊断中的应用价值。方法:选择2022年1—12月荆州市第三人民医院收治的216例疑似肺结核患者,将病理学诊断作为“金标准”,依据是否存在结核病进行分组,分为肺结核组(n=151)和非肺结核组(n=65),采集患者清晨空腹静脉血分别检测TB-IGRA、TB-Ab水平,观察两项指标检测肺结核阳性结果,观察不同检查方式诊断效能。结果:肺结核组中TB-IGRA阳性检出率、TB-Ab阳性检出率均高于非肺结核组,差异有统计学意义(P<0.05)。TB-IGRA、TB-Ab诊断肺结核的阳性预测值、特异度比较,差异无统计学意义(P>0.05),TB-IGRA诊断肺结核的敏感度、阴性预测值高于TB-Ab,差异有统计学意义(P<0.05)。年龄>60岁肺结核患者TB-IGRA阳性检出率、TB-Ab阳性检出率高于≤60岁肺结核患者,差异有统计学意义(P<0.05)。结论:临床肺结核诊断中应用TB-IGRA、TB-Ab检查均有较高诊断效能,但相对而言TB-IGRA检查方式更优,且该检查方式阳性率易受年龄因素影响。
Objective:To explore the diagnostic value of tubercle bacillus-T cell interferon-γrelease assays(TB-IGRA)and tubercle bacillus antibody(TB-Ab)in patients with pulmonary tuberculosis.Method:A total of 216 patients with suspected pulmonary tuberculosis admitted to the Third People's Hospital of Jingzhou from January to December 2022 were selected,and pathological diagnosis was taken as the"gold standard".According to the presence or absence of pulmonary tuberculosis,the patients were divided into pulmonary tuberculosis group(n=151)and non-pulmonary tuberculosis group(n=65).Fasting venous blood of patients in the morning was collected to detect TB-IGRA and TB-Ab levels respectively,and the positive results of the two indicators were observed and the diagnostic efficacy of different examination methods were compared.Result:The positive detection rates of TB-IGRA and TB-Ab in pulmonary tuberculosis group were higher than those in non-pulmonary tuberculosis group,and the differences were statistically significant(P<0.05).There were no there significant differences in the positive predictive value and specificity of diagnosis between TB-IGRA and TB-AB(P>0.05),while the sensitivity and negative predictive value of TB-IGRA were higher than those of TB-AB,the differences were statistically significant(P<0.05).The positive detection rate of TB-IGRA and TB-Ab in>60 years old patients with pulmonary tuberculosis were higher than those in≤60 years old patients with pulmonary tuberculosis,and the differences were statistically significant(P<0.05).Conclusion:The application of TB-IGRA and TB-Ab in clinical diagnosis of pulmonary tuberculosis has higher diagnostic efficacy,but the TB-IGRA examination is relatively better,but the positive rate of this examination is easily affected by age factors.
作者
刘小寒
LIU Xiaohan(The Third People's Hospital of Jingzhou,Jingzhou 434000,China)
出处
《中外医学研究》
2024年第1期67-70,共4页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
肺结核
结核感染T细胞γ干扰素释放试验
结核杆菌抗体
阳性检出率
诊断效能
Pulmonary tuberculosis
Tubercle bacillus-T cell interferon-γrelease assays
Tubercle bacillus antibody
Positive detection rate
Diagnostic efficacy
