摘要
目的:探究早期强化他汀干预联合曲克芦丁对急性脑梗死患者神经功能及近期预后的影响。方法:将2022年7月—2023年8月贵溪市人民医院收治的80例急性脑梗死患者作为研究对象。根据患者接受的不同治疗方案进行分组,将接受常规剂量他汀干预联合曲克芦丁治疗的患者纳入常规剂量组(n=39),将接受早期强化剂量他汀干预联合曲克芦丁治疗的患者纳入强化剂量组(n=41),治疗周期均为7 d。观察两组治疗效果、治疗前后神经功能[美国国立卫生研究院卒中量表(NIHSS)评分]、日常生活能力(Barthel指数)、血液流变学指标[血小板聚集率(PAR)、纤维蛋白原(FIB)、红细胞压积(HCT)]、血流动力学指标[脑动脉平均血流速度(Vm)、阻力指数(RI)、搏动指数(PI)]及治疗期间不良反应(心律失常、红疹、头晕)发生情况。结果:强化剂量组的治疗总有效率为87.80%,高于常规剂量组的69.23%(P<0.05);治疗后,强化剂量组NIHSS评分低于常规剂量组,Barthel指数高于常规剂量组(P<0.05);治疗后,强化剂量组PAR、FIB、HCT均低于常规剂量组(P<0.05);治疗后,强化剂量组Vm高于常规剂量组,RI、PI均低于常规剂量组(P<0.05);强化剂量组治疗期间不良反应发生率为14.63%,常规剂量组治疗期间不良反应发生率为10.26%,两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:早期强化他汀干预联合曲克芦丁能够提高急性脑梗死患者的治疗效果,改善脑部血流,有助于改善患者近期预后且具有较高安全性。
Objective:To explore the effect of early intensive statin intervention combined with Troxerutin on neurological function and short-term prognosis in patients with acute cerebral infarction.Method:A total of 80 patients with acute cerebral infarction treated in Guixi People's Hospital from July 2022 to August 2023 were selected as the study objects.Patients were divided into two groups according to different treatment schemes.Patients who received regular-dose statin intervention combined with Troxerutin were included in the regular dose group(n=39),and patients who received early intensive dose statin intervention combined with Troxerutin were included in the intensive dose group(n=41),the treatment cycle were 7 days.The curative effect,before and after treatment of neurological function[national institute of health stroke scale(NIHSS)],ability of daily living(Barthel index),hemorheology indexes[platelet aggregation rate(PAR),fibrinogen(FIB),hematocrit(HCT)]and cerebral hemodynamics indexes[mean flow velocity(Vm),resistance index(RI),pulsatility index(PI)],and the occurrence of adverse reactions(arrhythmia,rash,dizziness)during treatment in the two groups were observed.Result:The total effective rate of intensive dose group was 87.80%,which was higher than 69.23%of regular dose group(P<0.05).After treatment,NIHSS score in intensive dose group was lower than that in regular dose group,and Barthel index was higher than that in regular dose group(P<0.05).After treatment,PAR,FIB and HCT in intensive dose group were lower than those in regular dose group(P<0.05).After treatment,Vm in intensive dose group was higher than that in regular dose group,RI and PI were lower than those in regular dose group(P<0.05).The incidence of adverse reactions during treatment was 14.63%in the intensive dose group and 10.26%in the regular dose group.There was no statistical significance in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Early intensive statin intervention combined with Troxerutin can improve
作者
吴金秀
WU Jinxiu(Department of Internal MedicineⅠ,Guixi People's Hospital,Guixi 335400,China)
出处
《中国医学创新》
CAS
2024年第10期141-145,共5页
Medical Innovation of China
关键词
他汀类药物
曲克芦丁
急性脑梗死
神经功能
Statin Troxerutin
Acute cerebral infarction
Neurological function
