摘要
目的探讨人表皮生长因子受体2(HER2)阳性乳腺癌HER2表达水平与超声影像学、乳腺X线影像学检查特征的关系。方法收集2014年1月至2021年12月于哈尔滨医科大学附属肿瘤医院就诊的486例HER2阳性乳腺癌患者的影像学资料。分析HER2表达水平与乳腺超声影像学及乳腺X线影像学特征的关系。结果HER2阳性乳腺癌患者中HER22+占49.38%(240/486),HER23+占50.62%(246/486)。HER22+患者的年龄[(52.88±1.16)岁]大于HER23+患者的年龄[(49.59±1.00)岁],差异有统计学意义(t=18.07,P<0.001);HER22+患者与HER23+患者的月经状态差异有统计学意义(χ^(2)=4.42,P=0.036)。HER22+患者与HER23+患者在超声示毛刺征(χ^(2)=8.37,P=0.010)、后方回声(χ^(2)=9.68,P=0.017)、腋窝淋巴结肿大(χ^(2)=15.77,P<0.001)方面,差异均有统计学意义;HER22+患者与HER23+患者在乳腺X线影像学示有无肿块方面,差异有统计学意义(χ^(2)=15.81,P<0.001)。结论HER2阳性乳腺癌HER2表达水平与超声示毛刺征、后方回声、腋窝淋巴结肿大,乳腺X线影像学示有无肿块相关,可为临床预测乳腺癌的恶性程度、预估预后及个体化治疗方案的制定提供一定的信息。
Objective To investigate the relationships between the expression level of human epidermal growth factor receptor 2(HER2)in HER2-positive breast cancer and the characteristics of ultrasound imaging and mammography.Methods The imaging data of 486 patients with HER2-positive breast cancer treated in the Harbin Medical University Cancer Hospital from January 2014 to December 2021 were retrospectively collected.The relationships between the expression level of HER2 and the imaging features of breast ultrasound and mammography were analyzed.Results 49.38%(240/486)of HER2-positive breast cancer patients were HER22+,and 50.62%(246/486)of HER2-positive breast cancer patients were HER23+.The age of HER22+patients[(52.88±1.16)years]was older than the age of HER23+patients[(49.59±1.00)years],and there was a statistically significant difference(t=18.07,P<0.001).There was a statistically significant difference of menstrual status between HER22+patients and HER23+patients(χ^(2)=4.42,P=0.036).There were statistically significant differences in the ultrasonography showed burr sign(χ^(2)=8.37,P=0.010),posterior echo(χ^(2)=9.68,P=0.017),axillary lymph node enlargement(χ^(2)=15.77,P<0.001)between HER22+patients and HER23+patients.There was a statistically significant difference in the mammography showed whether there were lumps between HER22+patients and HER23+patients(χ^(2)=15.81,P<0.001).Conclusion The expression level of HER2 in HER2-positive breast cancer patients is related to burr sign,posterior echo,and axillary lymph node enlargement shown by ultrasound,as well as lumps shown by mammography,which can provide certain information for clinical prediction of malignant degree of breast cancer,prognosis and individualized treatment plan.
作者
冯诚天
黄芙蓉
曹世玉
王健宇
南丁阿比雅思
姜永冬
朱娟英
Feng Chengtian;Huang Furong;Cao Shiyu;Wang Jianyu;Nanding Abiyasi;Jiang Yongdong;ZhuJuanying(Department of Breast,Jiaxing Maternity and Child Health Care Hospital of Zhejiang Province,Jiaxing 314000,China;First Ward of Department of Breast Surgery,Harbin Medical University Cancer Hospital,Harbin 150081,China;Fourth Department of General Surgery,Xiangyang No.1 People's Hospital of Hubei Province,Xiangyang 441000,China;Department of Pathology,Harbin Medical University Cancer Hospital,Harbin 150081,China)
出处
《国际肿瘤学杂志》
CAS
2023年第9期527-531,共5页
Journal of International Oncology
基金
黑龙江省博士后科研基金(LBH-Q20133)。
