摘要
目的:分析宫颈癌中Krüpple样转录因子12(KLF12),信号转导和转录激活因子3(STAT3)的表达,并探讨其与临床病理特征和预后的相关性。方法:收集2017年07月至2020年07月收治于本院的82例宫颈癌患者活检及手术宫颈癌标本。采用免疫组化法检测患者宫颈癌组织及宫颈癌KLF12、STAT3表达情况。通过χ^(2)检验分析KLF12、STAT3表达与宫颈癌患者临床病理特征的关系。采用多因素Cox回归分析宫颈癌患者预后的相关因素。绘制Kaplan-Meier曲线分析KLF12、STAT3表达与宫颈癌患者3年生存率的关系。结果:宫颈癌组织KLF12阳性表达率高于癌旁组织(P<0.05),STAT3阳性表达率高于癌旁组织(P<0.05)。不同年龄、产次、月经状态、肿瘤直径、组织学分类、浸润深度患者宫颈癌组织中KLF12、STAT3表达差异无统计学意义(P>0.05)。FIGO分期Ⅱ期、低分化、有淋巴结转移的宫颈癌患者组织中KLF12、STAT3阳性表达率较高(P<0.05)。多因素Cox回归分析显示,FIGO分期Ⅱ期、KLF12、STAT3阳性表达均是宫颈癌患者3年内死亡的独立危险因素(P<0.05)。Kaplan-Meier曲线结果显示,KLF12阳性表达患者3年生存率66.66%(28/42)低于KLF12阴性表达患者90.00%(36/40)(P<0.05),STAT3阳性表达患者3年生存率70.49%(43/61)低于STAT3阴性表达患者100%(21/21)(P<0.05)。结论:宫颈癌组织中KLF12、STAT3阳性表达升高,两者异常表达与FIGO分期、分化程度、淋巴结转移及预后有关,可作为用于评估预后的生物标志物。
Objective:To analyze the expression of Krüpple-like transcription factor 12(KLF12)and signal transducer and activator of transcription 3(STAT3)in cervical cancer,and to explore its correlation with clinicopathological features and prognosis.Methods:The biopsy and surgical cervical cancer specimens of 82 patients with cervical cancer admitted to our hospital from July 2017 to July 2020 were collected.Immunohistochemistry was used to detect the expression of KLF12 and STAT3 in cervical cancer tissues and cervical cancer.The relationship between the expression of KLF12 and STAT3 and the clinicopathological features of cervical cancer patients was analyzed by χ^(2) test.Multivariate Cox regression was used to analyze the prognostic factors of cervical cancer patients.The relationship between the expression of KLF12 and STAT3 and the 3-year survival rate of patients with cervical cancer was analyzed by Kaplan-Meier curve.Results:The positive expression rate of KLF12 in cervical cancer tissues was higher than that in adjacent tissues(P<0.05),and the positive expression rate of STAT3 was higher than that in adjacent tissues(P<0.05).There was no significant difference in the expression of KLF12 and STAT3 in cervical cancer tissues of patients with different ages,parities,menstrual statuses,tumor diameters,histological classifications and depths of invasion(P>0.05).KLF12 and STAT3 were positively expressed in cervical cancer tissues of patients with FIGO stageⅡ,poor differentiation and lymph node metastasis(P<0.05).Multivariate Cox regression analysis showed that FIGO stageⅡ,KLF12 and STAT3 positive expression were independent risk factors for death in patients with cervical cancer within 3 years(P<0.05).The results of Kaplan-Meier curve showed that the 3-year survival rate of patients with positive expression of KLF12 was 66.66%(28/42),lower than that of patients with negative expression of KLF1290.00%(36/40)(P<0.05).The 3-year survival rate of patients with positive expression of STAT3 was 70.49%(43/61),lower than
作者
何永亮
章培
吴宁
蒋炳林
成永莲
欧阳海英
涂媛
HE Yongliang;ZHANG Pei;WU Ning;JIANG Binglin;CHENG Yonglian;OUYANG Haiying;TU Yuan(Pathology Department,the Second People's Hospital of Deyang City,Sichuan Deyang 618000,China;Department of Pathology,the Second People's Hospital of Chengdu,Sichuan Chengdu 610017,China;Laboratory Department,the Second People's Hospital of Deyang City,Sichuan Deyang 618000,China)
出处
《现代肿瘤医学》
CAS
2024年第7期1305-1310,共6页
Journal of Modern Oncology
基金
四川省科技计划项目(编号:2020YFG0377)。
关键词
宫颈癌
KLF12基因
信号转导和转录激活因子3
临床病理特征
预后
cervical cancer
KLF12 gene
signal transducer and activator of transcription 3
clinicopathological features
prognosis
