摘要
目的分析血清上皮细胞膜结合黏液素1(MUC1)、α1-酸性糖蛋白(AAG)水平与急性胆囊炎病人炎症以及预后的关系。方法收集2020年7月至2022年4月内蒙古北方医院收治的急性胆囊炎病人136例,病人根据严重程度分为轻度组、中度组与重度组,另选取同期体检健康者130例作为对照组,制备研究对象血清标本,ELISA法检测血清MUC1、AAG水平,比较对照组与急性胆囊炎组、不同严重程度急性胆囊炎病人白细胞计数、中性粒细胞、血清总胆红素、血清MUC1、AAG、C反应蛋白(CRP)水平;根据急性胆囊炎病人治疗后预后情况将病人分为预后良好组与预后不良组,比较两组血清MUC1、AAG水平;lo⁃gistic回归分析血清MUC1、AAG水平与急性胆囊炎病人预后情况的关系;受试者操作特征(ROC)曲线分析血清MUC1、AAG水平对急性胆囊炎病人预后不良的预测价值。结果与对照组相比,急性胆囊炎组病人血清MUC1[(134.29±22.35)ng/L比(85.17±14.11)ng/L]、AAG水平[(0.84±0.14)g/L比(0.45±0.07)g/L]升高(P<0.05);与轻度组相比,中度组、重度组病人白细胞计数、中性粒细胞、血清总胆红素、血清MUC1、AAG、CRP水平升高(P<0.05);与中度组相比,重度组病人白细胞计数、中性粒细胞、血清总胆红素、血清MUC1、AAG、CRP水平升高(P<0.05);与预后良好组相比,预后不良组急性胆囊炎病人血清MUC1、AAG升高(P<0.05);血清MUC1、AAG是急性胆囊炎病人预后不良的危险因素(P<0.05);血清MUC1、AAG、二者联合检测对急性胆囊炎病人预后不良的预测AUC分别为0.80(灵敏度为61.4%,特异度为86.4%)、0.81(灵敏度为95.5%,特异度为53.4%)、0.88(灵敏度为88.6%,特异度为79.5%)。结论血清MUC1、AAG在急性胆囊炎中均升高,且与病人的炎症程度有关,对病人术后预后不良具有较高预测作用。
Objective To analyze the relationship between serum epithelial cell membrane-bound mucin 1(MUC1)andα1-acid gly⁃coprotein(AAG)levels and inflammation and prognosis in patients with acute cholecystitis.Methods One hundred and thirty-six pa⁃tients with acute cholecystitis admitted to the North Hospital of Inner Mongolia from July 2020 to April 2022 were collected.The pa⁃tients were assigned into mild group,moderate group and severe group according to the severity,another 130 healthy subjects who un⁃derwent physical examination were selected as the control group.Serum samples of research subjects were prepared,the levels of serum MUC1 and AAG were detected by ELISA,and the levels of white blood cell count,neutrophils,serum MUC1,AAG and C-reactive pro⁃tein(CRP)levels in patients with acute cholecystitis of different severitywere compared between the control group and the acute chole⁃cystitis group;according to the prognosis of patients with acute cholecystitis after treatment,the patients were assigned into a good prog⁃nosis group and a poor prognosis group,and the levels of serum MUC1 and AAG were compared between the two groups.Logistic re⁃gression was performed to analyze the relationship between serum MUC1 and AAG levels and the prognosis of patients with acute chole⁃cystitis;receiver operating characteristic(ROC)curve was performed to analyze the predictive value of serum MUC1 and AAG levels for poor prognosis in patients with acute cholecystitis.Results Compared with the control group,the serum levels of MUC1[(134.29±22.35)ng/L vs.(85.17±14.11)ng/L]and AAG[(0.84±0.14)g/L vs.(0.45±0.07)g/L]in the acute cholecystitis group were significantly in⁃creased(P<0.05);compared with the mild group,the levels of white blood cell count,neutrophils,serum MUC1,AAG and CRP in the moderate group and severe group were increased(P<0.05);compared with the moderate group,the levels of white blood cell count,neu⁃trophils,serum MUC1,AAG and CRP in the severe group were increased(P<0.05);compared with the goo
作者
沙爽
SHA Shuang(Department of General Surgery,Inner Mongolia North Hospital(the Third Clinical Medical College of Baotou Medical College),Baotou,Inner Mongolia Autonomous Region 014030,China)
出处
《安徽医药》
CAS
2024年第5期962-965,共4页
Anhui Medical and Pharmaceutical Journal
关键词
胆囊炎
急性
上皮细胞膜结合黏液素1
Α1-酸性糖蛋白
胆道炎症
预后
Cholecystitis,acute
Epithelial cell membrane-binding mucin 1
α1-acid glycoprotein
Biliary tract inflammation
Prognosis
