摘要
目的探讨血清上皮细胞膜结合黏液素1(MUC1)、可溶性髓样细胞触发受体1(sTREM-1)水平与溃疡性结肠炎(UC)病情严重程度以及临床结局的关系。方法选择153例UC患者,根据病情严重程度分为轻度组(49例)、中度组(65例)、重度组(39例),根据黏膜病理学检查结果分为活动期组(91例)和缓解期组(62例),根据临床结局分为好转组(106例)和未好转组(47例),另选择82例健康志愿者为对照组。采用酶联免疫吸附试验法检测血清MUC1、sTREM-1水平,采用受试者工作特征(ROC)曲线分析MUC1、sTREM-1以及MUC1+sTREM-1预测UC患者临床结局的价值。结果UC组血清MUC1、sTREM-1水平高于对照组(P均<0.01),重度组血清MUC1、STREM-1水平高于中度组和轻度组(P均<0.01),中度组血清MUC1、sTREM-1水平高于轻度组(P均<0.01)。活动期组血清MUC1、sTREM-1水平高于缓解期组(P均<0.01),好转组血清MUC1、sTREM-1水平低于未好转组(P均<0.01)。MUC1、sTREM-1截断值为18.42 U/mL、159.35 pg/mL时,预测UC患者经临床治疗后未好转的曲线下面积(AUC)分别为0.706、0.699,MUC1、sTREM-1联合预测UC患者经临床治疗后未好转的AUC为0.903,高于MUC1、sTREM-1单独检测(P均<0.05)。结论UC患者血清MUC1、sTREM-1水平均升高,且与患者病情严重程度和临床结局有关,可作为评估UC临床结局的潜在指标。
Objective To investigate the relationships between serum epithelial membrane binding mucin 1(MUC1)and soluble triggering receptor expressed on myeloid cell-1(sTREM-1)levels and severity of illness and clinical outcome of ulcerative colitis(UC).Methods According to the severity of illness,153 cases of patients with UC were divided into the mild group(49 cases),moderate group(65 cases),and severe group(39 cases);according to the result of mucosal pathology examination,patients were divided into the active period group(91 cases)and the remission group(62 cases);according to the clinical outcome,patients were divided into the improved group(106 cases)and non-improved group(47 cases).Another 82 healthy volunteers were selected as the control group.Serum levels of MUC1 and sTREM-1 were detected by ELISA.The value of MUC1,sTREM-1 and MUC1+sTREM-1 in predicting clinical outcome of UC patients was analyzed by receiver operating characteristic(ROC)curve.Results Serum MUC1,sTREM-1 levels in the UC group were higher than those in the control group(both P<0.01).Serum MUC1,sTREM-1 levels in the severe group were higher than those in moderate and mild groups(all P<0.01).Serum MUC1,sTREM-1 levels in the moderate group were higher than those in the mild group(both P<0.01).Serum MUC1,sTREM-1 levels in the active group were higher than those in the remission group(both P<0.01),and those in the improved group were lower than those in the non-improved group(both P<0.01).When the cut-off values of MUC1 and sTREM-1 were 18.42 U/ml and 159.35 pg/mL,the area under the curve(AUC)for predicting UC patients without better improvement after clinical treatment were 0.706 and 0.699,respectively,and the AUC of UC combined with MUC1 and sTREM-1 was 0.903,which was higher than that of MUC1 and sTREM-1 alone(all P<0.05).Conclusion Serum MUC1 and sTREM-1 levels increase in patients with UC,and are related to severity of illness and clinical outcome,which can be used as the potential indicators to evaluate the clinical outcome of UC.
作者
羊丹
徐菁
陈保银
马竹芳
YANG Dan;XU Jing;CHEN Baoyin;MA Zhufang(Gastroenterology Department,3201 Hospital,Hanzhong 723000,China)
出处
《山东医药》
CAS
2021年第28期38-41,共4页
Shandong Medical Journal
基金
陕西省自然科学基金项目(2018JM01054)。
关键词
溃疡性结肠炎
上皮细胞膜结合黏液素l
可溶性髓样细胞触发受体1
病情严重程度
临床结局
ulcerative colitis
membrane-bound mucin-I of epithelial cells
soluble triggering receptor expressed on myeloid cell-1
severity of illness
clinical outcome
