摘要
目的探讨胃食管反流病(Gastroesophageal reflux disease,GERD)患者焦虑、抑郁的危险因素。方法回顾性分析某三甲医院门诊177例GERD患者基本信息及临床资料,根据焦虑抑郁评分将患者分为两组:合并焦虑或抑郁组、未合并焦虑或抑郁组。采用单因素及多因素Logistic回归分析探索GERD患者合并焦虑或抑郁情绪的危险因素。结果纳入的177例GERD患者49.7%合并焦虑或抑郁,而便秘(OR=2.289,95%CI 1.138-4.605,P<0.05)、咽喉反流(OR=2.226,95%CI1.112-4.459,P<0.05)、睡眠质量差(OR=3.786,95%CI 1.900-7.544,P<0.05)、半年内经历压力性事件(OR=4.569,95%CI 1.643-12.706,P<0.05)是GERD患者发生焦虑或抑郁的独立危险因素。结论胃食管反流病合并焦虑或抑郁状态发生率高,便秘、咽喉反流、睡眠质量差及半年内经历压力性事件是GERD患者合并焦虑或抑郁状态的独立危险因素,临床工作中应给予针对性的干预措施以减少焦虑抑郁的发生。
Objective To investigate the risk factors associated with anxiety and depression in patients with gastro-esophageal reflux disease(Gastroesophageal reflux disease,GERD).Methods A retrospective study was conducted on the basic formation of clinical data of 177 outpatients with GERD in a tertiary hospital.Based on the scores obtained from the Hospital Anxiety and Depression Scale,the patients were divided into two groups:patients with symptoms of anxiety or depression group,and patients without symptoms of anxiety or depression group.Univariate and multivariate Logistic regression analysis were performed to identify the risk factors contributing to comorbid anxiety or depressed mood in pa-tients with GERD.Results Among the 177 patients with GERD,49.7%of the patients had comorbid anxiety or depres-sion.The presence of constipation(OR=2.289,95%CI 1.138-4.605,P<0.05),laryngopharyngeal reflux(OR=2.226,95%CI 1.112-4.459,P<0.05),poor sleep quality(OR=3.786,95%CI 1.900-7.544,P<0.05),and experiencing stressful events within a six-month period(OR=4.569,95%CI 1.643-12.706,P<0.05)were independent risk factors for anxiety or depression in patients with GERD.Conclusion The incidence of anxiety or depression is high in patients with GERD.Constipation,laryngopharyngeal reflux,poor sleep quality,and stressful events within a six-month period are independent risk factors for anxiety or depression in patients with GERD.Targeted interventions should be provided in clinical practice to reduce the incidence of anxiety or depression in GERD patients.
作者
马巾茹
柴红
宫璇
谭诗云
卢筱洪
王高华
MA Jinru;CHAI Hong;GONG Xuan(Renmin Hospital of Wuhan University,Wuhan 430060,China)
出处
《国际精神病学杂志》
2024年第1期236-240,252,共6页
Journal Of International Psychiatry
基金
武汉大学医学部建设项目(编号:TFLC2018001)。
关键词
胃食管反流病
焦虑
抑郁
咽喉反流
睡眠质量
Gastroesophageal reflux disease
Anxiety
Depression
Laryngeal reflux
Sleep quality
